Literature DB >> 8103466

Cloning and expression of a cDNA for the rat kappa-opioid receptor.

M Minami1, T Toya, Y Katao, K Maekawa, S Nakamura, T Onogi, S Kaneko, M Satoh.   

Abstract

We cloned a cDNA for the rat kappa-opioid receptor from a rat thalamus cDNA library. The deduced amino acid sequence consists of 380 residues with features shared by members of the G protein-coupled receptor family. The specific binding of [3H]bremazocine to the membrane of COS-7 cells transfected with the cDNA was displaced by kappa-specific opioid ligands, but not by mu- and delta-specific ligands. Xenopus oocytes injected with the in vitro transcribed mRNA responded to opioid ligands with the same subtype specificity. Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain.

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Year:  1993        PMID： 8103466     DOI： 10.1016/0014-5793(93)80240-u

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  30 in total

1.  Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

Authors:  M G Darlison; F R Greten; R J Harvey; H J Kreienkamp; T Stühmer; H Zwiers; K Lederis; D Richter
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

Review 2.  Ligand-directed signalling within the opioid receptor family.

Authors:  Amynah A Pradhan; Monique L Smith; Brigitte L Kieffer; Christopher J Evans
Journal:  Br J Pharmacol       Date:  2012-11       Impact factor: 8.739

Review 3.  Advances in opioid pharmacology.

Authors:  Geoffrey K Gourlay
Journal:  Support Care Cancer       Date:  2004-12-21       Impact factor: 3.603

4.  The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids.

Authors:  U Arvidsson; M Riedl; S Chakrabarti; L Vulchanova; J H Lee; A H Nakano; X Lin; H H Loh; P Y Law; M W Wessendorf
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

5.  Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia.

Authors:  I Sora; N Takahashi; M Funada; H Ujike; R S Revay; D M Donovan; L L Miner; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

Review 6.  Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides.

Authors:  B L Kieffer
Journal:  Cell Mol Neurobiol       Date:  1995-12       Impact factor: 5.046

Review 7.  The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us?

Authors:  Ji Hoon Yoo; Ian Kitchen; Alexis Bailey
Journal:  Br J Pharmacol       Date:  2012-08       Impact factor: 8.739

8.  Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic).

Authors:  Chad M Kormos; Pauline W Ondachi; Scott P Runyon; James B Thomas; S Wayne Mascarella; Ann M Decker; Hernán A Navarro; Timothy R Fennell; Rodney W Snyder; F Ivy Carroll
Journal:  J Med Chem       Date:  2018-08-29       Impact factor: 7.446

Review 9.  Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity.

Authors:  Paul E Micevych; Kevin Sinchak
Journal:  Horm Behav       Date:  2018-05-18       Impact factor: 3.587

10.  Affinity labeling mu opioid receptors with novel radioligands.

Authors:  Ke Yang; Amy Zuckerman; Gavril W Pasternak
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046
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