OBJECTIVE: To assess and compare the accuracy of imaging methods (ultrasonography (US), computed tomography (CT), angiography, arterially enhanced CT with computed tomographic arterial portography (CTA)), biochemical analyses, and surgical assessment during the operation, in detecting the presence of absence of hepatic metastases in patients with colorectal cancer. DESIGN: Open study. SETTING: University of Lund, Sweden. SUBJECTS: 71 consecutive patients without clinical evidence of liver metastases at the time of the operation for removal of the primary tumour. INTERVENTIONS: Regular biochemical tests for five to seven years, and CT and US one year after operation in all patients without confirmed metastases. MAIN OUTCOME MEASURES: Presence or absence of hepatic metastases. RESULTS: Accuracy of surgical assessment, angiography, US, CT and CTA was 90, 77, 80, 82 and 83%, respectively, and corresponding predictive values of a negative test were 87, 75, 77, 80 and 84%. Measurement of bilirubin concentration and hepatic enzyme activities were not helpful, and that of carcinoembryonic antigen had an accuracy of only 70%. Accuracy and predictive values were not improved by combining tests. CONCLUSION: The accuracy of US, CT or CTA was not good enough to merit routine use before operations for colorectal cancer. They are potentially valuable for monitoring progress at follow up, but this remains to be confirmed.
OBJECTIVE: To assess and compare the accuracy of imaging methods (ultrasonography (US), computed tomography (CT), angiography, arterially enhanced CT with computed tomographic arterial portography (CTA)), biochemical analyses, and surgical assessment during the operation, in detecting the presence of absence of hepatic metastases in patients with colorectal cancer. DESIGN: Open study. SETTING: University of Lund, Sweden. SUBJECTS: 71 consecutive patients without clinical evidence of liver metastases at the time of the operation for removal of the primary tumour. INTERVENTIONS: Regular biochemical tests for five to seven years, and CT and US one year after operation in all patients without confirmed metastases. MAIN OUTCOME MEASURES: Presence or absence of hepatic metastases. RESULTS: Accuracy of surgical assessment, angiography, US, CT and CTA was 90, 77, 80, 82 and 83%, respectively, and corresponding predictive values of a negative test were 87, 75, 77, 80 and 84%. Measurement of bilirubin concentration and hepatic enzyme activities were not helpful, and that of carcinoembryonic antigen had an accuracy of only 70%. Accuracy and predictive values were not improved by combining tests. CONCLUSION: The accuracy of US, CT or CTA was not good enough to merit routine use before operations for colorectal cancer. They are potentially valuable for monitoring progress at follow up, but this remains to be confirmed.
Authors: Jeong Min Lee; Ji Hyun Youk; Young Hwan Lee; Young Kon Kim; Chong Soo Kim; Chun Ai Li Journal: Korean J Radiol Date: 2003 Apr-Jun Impact factor: 3.500
Authors: Pier Paolo Mainenti; Federica Romano; Laura Pizzuti; Sabrina Segreto; Giovanni Storto; Lorenzo Mannelli; Massimo Imbriaco; Luigi Camera; Simone Maurea Journal: World J Radiol Date: 2015-07-28