Literature DB >> 8102674

Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slow-acting anti-rheumatic drugs.

J A Hamilton1.   

Abstract

The pathogenesis of rheumatoid arthritis and the mode of action of anti-rheumatic drugs are unknown. This hypothesis proposes that haemopoietic growth factors (colony stimulating factors [CSFs]) have an important role in rheumatoid arthritis as regulators of myelopoiesis and as activators of inflammatory leucocytes. It also suggests that slow-acting anti-rheumatic drugs may work by inhibiting myelopoiesis. This opposition to one of the actions of the CSFs would result in fewer inflammatory cells in the inflamed joints.

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Year:  1993        PMID： 8102674     DOI： 10.1016/0140-6736(93)91653-4

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  27 in total

1.  Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice.

Authors:  I K Campbell; A Bendele; D A Smith; J A Hamilton
Journal:  Ann Rheum Dis       Date:  1997-06       Impact factor: 19.103

Review 2.  Averting inflammation by targeting the cytokine environment.

Authors:  Manfred Kopf; Martin F Bachmann; Benjamin J Marsland
Journal:  Nat Rev Drug Discov       Date:  2010-09       Impact factor: 84.694

3.  Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation.

Authors:  R J Bischof; D Zafiropoulos; J A Hamilton; I K Campbell
Journal:  Clin Exp Immunol       Date:  2000-02       Impact factor: 4.330

4.  [Prostate cancer screening with a new marker based on circulating blood macrophages?].

Authors:  R Herwig; B Djavan; G Kramer; M A El-Taieb; F Kühhas; M Leers; M Marberger
Journal:  Urologe A       Date:  2007-09       Impact factor: 0.639

Review 5.  Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage.

Authors:  Irina Ushach; Albert Zlotnik
Journal:  J Leukoc Biol       Date:  2016-06-28       Impact factor: 4.962

6.  GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

Authors:  Roselind S Lam; Neil M O'Brien-Simpson; John A Hamilton; Jason C Lenzo; James A Holden; Gail C Brammar; Rebecca K Orth; Yan Tan; Katrina A Walsh; Andrew J Fleetwood; Eric C Reynolds
Journal:  Immunol Cell Biol       Date:  2015-03-10       Impact factor: 5.126

7.  TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17.

Authors:  Andrew D Cook; Ming-Chin Lee; Reem Saleh; Hsu-Wei Khiew; Anne D Christensen; Adrian Achuthan; Andrew J Fleetwood; Derek C Lacey; Julia E Smith; Irmgard Förster; John A Hamilton
Journal:  JCI Insight       Date:  2018-03-22

8.  Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF.

Authors:  Jesper Worm; Jan Stenvang; Andreas Petri; Klaus Stensgaard Frederiksen; Susanna Obad; Joacim Elmén; Maj Hedtjärn; Ellen Marie Straarup; Jens Bo Hansen; Sakari Kauppinen
Journal:  Nucleic Acids Res       Date:  2009-07-13       Impact factor: 16.971

9.  Positive influence of Methotrexate-Hydroxychloroquine combination on the expression of GM-CSF receptor on neutrophils of synovial fluid in rheumatoid arthritis.

Authors:  Ananth N Rao; Beena V Shetty; D M Vasudevan
Journal:  Indian J Clin Biochem       Date:  2006-09

Review 10.  Investigational therapies targeting the granulocyte macrophage colony-stimulating factor receptor-α in rheumatoid arthritis: focus on mavrilimumab.

Authors:  Andrew D Cook; John A Hamilton
Journal:  Ther Adv Musculoskelet Dis       Date:  2018-01-11       Impact factor: 5.346
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