| Literature DB >> 8102669 |
A de Francisco1, J Chakraborty, H R Chowdhury, M Yunus, A H Baqui, A K Siddique, R B Sack.
Abstract
A double-blind, randomised, placebo-controlled trial was conducted to evaluate the safety and toxicity of vitamin A supplementation within the Expanded Programme on Immunisation (EPI) in rural Bangladesh. 191 infants received 3 doses of either 50,000 IU of vitamin A or placebo at about 1.5, 2.5, and 3.5 months and were examined on days 1, 2, 3, and 8 after supplementation. 11 infants (11.5%) supplemented with vitamin A had episodes of bulging of the fontanelle as opposed to 1 (1%) in the placebo group. 16 of the 17 events occurred in the vitamin A supplemented group. No other side effects were noted. There was a tendency towards a cumulative effect of toxicity with increasing doses.Entities:
Keywords: Age Factors; Asia; Bangladesh; Biology; Clinical Research; Clinical Trials; Delivery Of Health Care; Demographic Factors; Developing Countries; Double-blind Studies; Food Supplementation; Health; Health Services; Immunization; Infant; Integrated Programs; Nutrition Programs; Organization And Administration; Physiology; Population; Population Characteristics; Primary Health Care; Programs; Research Methodology; Research Report; Southern Asia; Studies; Vaccines; Vitamin A--administraction and dosage; Vitamin A--side effects; Vitamins; Youth
Mesh：
Substances：
Year: 1993 PMID： 8102669 DOI： 10.1016/0140-6736(93)91648-6
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321