Literature DB >> 8102121

Effects of CD8 depletion on retinal soluble antigen induced experimental autoimmune uveoretinitis.

V L Calder1, Z S Zhao, Y Wang, K Barton, S L Lightman.   

Abstract

During the later stages of soluble-antigen (sAg)-induced experimental autoimmune uveoretinitis (EAU), an increase in the relative number of CD8+ lymphocytes has been observed at the site of inflammation in the retina. It has been suggested that these late-appearing CD8+ cells might down-regulate this acute disease process. To determine the role of the CD8+ cells in EAU, Lewis rats were depleted of CD8+ cells prior to and during disease and the enucleated eyes examined histologically. The spleen cells from CD8-depleted rats were also examined for their ability to respond to concanavalin A (Con A) and to allogeneic targets as determined by mixed lymphocyte reaction (MLR) and cytotoxicity assays. The results suggest that depleting CD8+ cells had no effect on the course of disease and that CD8+ cells do not play a crucial role in the immunoregulation of EAU.

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Year:  1993        PMID： 8102121      PMCID： PMC1421879     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  21 in total

1.  Long-term depletion of CD8+ T cells in vivo in the rat: no observed role for CD8+ (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis.

Authors:  J D Sedgwick
Journal:  Eur J Immunol       Date:  1988-04       Impact factor: 5.532

2.  Kinetics of T-lymphocyte subsets in the eyes of Lewis rats with experimental autoimmune uveitis.

Authors:  C C Chan; M Mochizuki; A G Palestine; D BenEzra; I Gery; R B Nussenblatt
Journal:  Cell Immunol       Date:  1985-12       Impact factor: 4.868

3.  Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina.

Authors:  W B Wacker; L A Donoso; C M Kalsow; J A Yankeelov; D T Organisciak
Journal:  J Immunol       Date:  1977-12       Impact factor: 5.422

4.  Isolation of encephalitogenic CD4+ T cell clones in the rat. Cloning methodology and interferon-gamma secretion.

Authors:  J D Sedgwick; I A MacPhee; M Puklavec
Journal:  J Immunol Methods       Date:  1989-07-26       Impact factor: 2.303

5.  In vivo treatment of rats with monoclonal anti-T-cell antibodies. Immunohistochemical and functional analysis in normal rats and in experimental allergic neuritis.

Authors:  R Holmdahl; T Olsson; T Moran; L Klareskog
Journal:  Scand J Immunol       Date:  1985-08       Impact factor: 3.487

6.  T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat.

Authors:  R R Caspi; F G Roberge; C G McAllister; M el-Saied; T Kuwabara; I Gery; E Hanna; R B Nussenblatt
Journal:  J Immunol       Date:  1986-02-01       Impact factor: 5.422

7.  T-lymphocyte subsets in experimental autoimmune uveitis.

Authors:  C C Chan; M Mochizuki; R B Nussenblatt; A G Palestine; C McAllister; I Gery; D BenEzra
Journal:  Clin Immunol Immunopathol       Date:  1985-04

8.  Treatment of murine lupus with F(ab')2 fragments of monoclonal antibody to L3T4. Suppression of autoimmunity does not depend on T helper cell depletion.

Authors:  N L Carteron; C L Schimenti; D Wofsy
Journal:  J Immunol       Date:  1989-03-01       Impact factor: 5.422

9.  Prevention of experimental autoimmune uveoretinitis and experimental autoimmune pinealitis in (Lewis x Brown-Norway) F1 rats by HgCl2 injections.

Authors:  A Saoudi; B Bellon; Y de Kozak; J Kuhn; M C Vial; B Thillaye; P Druet
Journal:  Immunology       Date:  1991-10       Impact factor: 7.397

10.  A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule.

Authors:  A M Livingstone; S J Powis; A G Diamond; G W Butcher; J C Howard
Journal:  J Exp Med       Date:  1989-09-01       Impact factor: 14.307
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  14 in total

Review 1.  Immunomodulation of autoimmune responses with monoclonal antibodies and immunoadhesins: treatment of ocular inflammatory disease in the next millennium.

Authors:  A D Dick; J D Isaacs
Journal:  Br J Ophthalmol       Date:  1999-11       Impact factor: 4.638

Review 2.  Tolerance and autoimmunity in the eye: a role for CD8 T cells in organ-specific autoimmunity in the retina.

Authors:  John V Forrester; Richard J Cornall
Journal:  Immunology       Date:  2003-11       Impact factor: 7.397

3.  Suppression of actively induced experimental autoimmune uveoretinitis by CD4+ T cells.

Authors:  E Uchio; M Kijima; M Ishioka; S Tanaka; S Ohno
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1997-02       Impact factor: 3.117

4.  Identification of a bone marrow-derived CD8αα+ dendritic cell-like population in inflamed autoimmune target tissue with capability of inducing T cell apoptosis.

Authors:  Jean Wu; Cindy Zhou; Julie Robertson; Connie C Y Weng; Marvin L Meistrich; Ramesh C Tailor; Ya-Huan Lou
Journal:  J Leukoc Biol       Date:  2010-07-13       Impact factor: 4.962

5.  AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells.

Authors:  So Jin Bing; Itay Shemesh; Wai Po Chong; Reiko Horai; Yingyos Jittayasothorn; Phyllis B Silver; Benjamin Sredni; Rachel R Caspi
Journal:  J Autoimmun       Date:  2019-03-08       Impact factor: 7.094

Review 6.  A look at autoimmunity and inflammation in the eye.

Authors:  Rachel R Caspi
Journal:  J Clin Invest       Date:  2010-09-01       Impact factor: 14.808

Review 7.  Experimental approaches to specific immunotherapies in autoimmune disease: future treatment of endogenous posterior uveitis?

Authors:  A D Dick
Journal:  Br J Ophthalmol       Date:  1995-01       Impact factor: 4.638

8.  Beneficial effect of dimethyl fumarate on experimental autoimmune uveitis is dependent of pro-inflammatory markers immunomodulation.

Authors:  Moussa Labsi; Imene Soufli; Houda Belguendouz; Sara Djebbara; Leila Hannachi; Zine-Charaf Amir; Chafia Touil-Boukoffa
Journal:  Inflammopharmacology       Date:  2021-09-13       Impact factor: 4.473

9.  Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype.

Authors:  Mary J Mattapallil; Phyllis B Silver; Lizette M Cortes; Anthony J St Leger; Yingyos Jittayasothorn; Jennifer L Kielczewski; James J Moon; Chi-Chao Chan; Rachel R Caspi
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-08       Impact factor: 4.799

10.  Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.

Authors:  Kohei Hosokawa; Pawel Muranski; Xingmin Feng; Danielle M Townsley; Baoying Liu; Jared Knickelbein; Keyvan Keyvanfar; Bogdan Dumitriu; Sawa Ito; Sachiko Kajigaya; James G Taylor; Mariana J Kaplan; Robert B Nussenblatt; A John Barrett; John O'Shea; Neal S Young
Journal:  J Immunol       Date:  2016-01-13       Impact factor: 5.422
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