Literature DB >> 8101833

Isolation and mapping of discrete DXS101 loci in Xq22 near the X-linked agammaglobulinaemia gene locus.

M A O'Reilly1, A K Sweatman, L D Bradley, L A Alterman, R Lovering, S Malcolm, R J Levinsky, C Kinnon.   

Abstract

The X-linked agammaglobulinaemia (XLA) gene locus has previously been mapped to Xq22 in genetic linkage studies. The DXS101 locus has shown no recombinations with XLA in the ten informative meioses investigated so far. The DXS101 sequence, recognised by the cX52.5 plasmid, is moderately repeated in Xq22. We have isolated cosmids which contain this sequence; two copies of which have been found to lie near DXS178 and XLA, and a third copy which lies near the PLP gene, distal to these loci. We have used the cosmids to generate probes which should be of use for RFLP analysis, and thus in both prenatal diagnosis and carrier testing for XLA, and in constructing a genetic map of this region. These probes will also be used to complement the genetic map in the construction of a complete physical map of Xq22.

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Year:  1993        PMID： 8101833     DOI： 10.1007/bf00205088

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  10 in total

Review 1.  Report of the committee on the genetic constitution of the X chromosome.

Authors:  K E Davies; J L Mandel; A P Monaco; R L Nussbaum; H F Willard
Journal:  Cytogenet Cell Genet       Date:  1990

2.  Construction, arraying, and high-density screening of large insert libraries of human chromosomes X and 21: their potential use as reference libraries.

Authors:  D Nizetić; G Zehetner; A P Monaco; L Gellen; B D Young; H Lehrach
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

3.  Close linkage of probe p212 (DXS178) to X-linked agammaglobulinemia.

Authors:  S Guioli; B Arveiler; B Bardoni; L D Notarangelo; P Panina; M Duse; A Ugazio; I Oberlé; G de Saint Basile; J L Mandel
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

4.  Efficient isolation of X chromosome-specific single-copy probes from a cosmid library of a human X/hamster hybrid-cell line: mapping of new probes close to the locus for X-linked mental retardation.

Authors:  M H Hofker; A A Bergen; M I Skraastad; N J Carpenter; H Veenema; J M Connor; E Bakker; G J van Ommen; P L Pearson
Journal:  Am J Hum Genet       Date:  1987-04       Impact factor: 11.025

5.  High-density genetic and physical mapping of DNA markers near the X-linked Alport syndrome locus: definition and use of flanking polymorphic markers.

Authors:  D F Barker; P R Fain; D E Goldgar; J N Dietz-Band; A E Turco; C E Kashtan; M C Gregory; K Tryggvason; M H Skolnick; C L Atkin
Journal:  Hum Genet       Date:  1991-12       Impact factor: 4.132

6.  Pulsed-field gel electrophoresis and radiation hybrid mapping analyses enable the ordering of eleven DNA loci in Xq22.

Authors:  M A O'Reilly; L A Alterman; J Zijlstra; S Malcolm; R J Levinsky; C Kinnon
Journal:  Genomics       Date:  1993-02       Impact factor: 5.736

7.  Physical mapping identifies DXS265 as a useful genetic marker for carrier detection and prenatal diagnosis of X-linked agammaglobulinemia.

Authors:  R Lovering; A K Sweatman; M A O'Reilly; S A Genet; H Middleton-Price; S Malcolm; R J Levinsky; C Kinnon
Journal:  Hum Genet       Date:  1993-03       Impact factor: 4.132

8.  Close linkage of random DNA fragments from Xq 21.3-22 to X-linked agammaglobulinaemia (XLA).

Authors:  S Malcolm; G de Saint Basile; B Arveiler; Y L Lau; P Szabo; A Fischer; C Griscelli; M Debre; J L Mandel; R E Callard
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132

9.  Identification of a closely linked DNA marker, DXS178, to further refine the X-linked agammaglobulinemia locus.

Authors:  S P Kwan; J Terwilliger; R Parmley; G Raghu; L A Sandkuyl; J Ott; H Ochs; R Wedgwood; F Rosen
Journal:  Genomics       Date:  1990-02       Impact factor: 5.736

10.  Identification of CpG islands around the DXS178 locus in the region of the X-linked agammaglobulinaemia gene locus in Xq22.

Authors:  M A O'Reilly; L A Alterman; S Malcolm; R J Levinsky; C Kinnon
Journal:  Hum Genet       Date:  1992-11       Impact factor: 4.132
  10 in total
  1 in total

1.  Physical mapping in the region of the Bruton's tyrosine kinase and alpha-galactosidase A gene loci in proximal Xq22.

Authors:  A K Sweatman; L A Bradley; R C Lovering; M A O'Reilly; R J Levinsky; C Kinnon
Journal:  Hum Genet       Date:  1994-12       Impact factor: 4.132
  1 in total

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