| Literature DB >> 8101586 |
A Feliciello1, A Porcellini, I Ciullo, G Bonavolontà, E V Avvedimento, G Fenzi.
Abstract
It is not clear whether the ophthalmopathy present in Graves' disease is related to autoimmune reactions to common thyroid/orbit components or is due to specific ocular antigens unrelated to the thyroid. In Graves' disease, serum antibodies to the thyrotropin receptor (TSH-R) can stimulate thyroid function, but no link between the TSH-R and ocular tissues has been found. We have shown, by polymerase chain reaction amplification of specific cDNA, that mature TSH-R mRNA is expressed in the retro-orbital tissue of both healthy subjects and patients with Graves' disease. Of other tissues and cells tested (fibroblasts, lymphocytes, muscle, and thyroid), only thyroid tissue expressed the TSH-R mRNA.Entities:
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Year: 1993 PMID： 8101586 DOI： 10.1016/0140-6736(93)91475-2
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321