Literature DB >> 8101370

Pituitary adenylate cyclase activating polypeptide (PACAP) is a potent relaxant of the rat ileum.

S Katsoulis1, A Clemens, H Schwörer, W Creutzfeldt, W E Schmidt.   

Abstract

The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not modified by TTX, omega-conotoxin, adrenergic, or ganglionic blockade, antagonists of adrenoreceptors and muscarinic receptors, indicating a direct myogenic effect probably through specific PACAP receptors. The lack of cross-tachyphylaxis between PACAP and VIP suggests that both peptides act by activation of distinct receptors. Structure-function analysis revealed that the N-terminal region of the PACAP molecule is crucial for biological activity.

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Year:  1993        PMID： 8101370     DOI： 10.1016/0196-9781(93)90149-b

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  5 in total

1.  PACAP Modulates Acetylcholine-Elicited Contractions at Nicotinic Neuromuscular Contacts of the Land Snail.

Authors:  Nóra Krajcs; László Hernádi; Zsolt Pirger; Dóra Reglődi; Gábor Tóth; Tibor Kiss
Journal:  J Mol Neurosci       Date:  2015-07-03       Impact factor: 3.444

2.  Electrophysiological analysis of the actions of pituitary adenylyl cyclase activating peptide in the taenia of the guinea-pig caecum.

Authors:  K McConalogue; D J Lyster; J B Furness
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-11       Impact factor: 3.000

3.  Investigation of the Role of Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Its Type 1 (PAC1) Receptor in Uterine Contractility during Endometritis in Pigs.

Authors:  Barbara Jana; Jarosław Całka; Krzysztof Witek
Journal:  Int J Mol Sci       Date:  2022-05-13       Impact factor: 6.208

4.  Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal.

Authors:  Mei Jin Wu; Keun Hong Kee; Jisun Na; Seok Won Kim; Youin Bae; Dong Hoon Shin; Seok Choi; Jae Yeoul Jun; Han-Seong Jeong; Jong-Seong Park
Journal:  Korean J Physiol Pharmacol       Date:  2015-08-20       Impact factor: 2.016

Review 5.  Adaptive Changes in the Central Control of Energy Homeostasis Occur in Response to Variations in Energy Status.

Authors:  Cassandra Gastelum; Lynnea Perez; Jennifer Hernandez; Nikki Le; Isabella Vahrson; Sarah Sayers; Edward J Wagner
Journal:  Int J Mol Sci       Date:  2021-03-08       Impact factor: 5.923
  5 in total

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