Literature DB >> 8101368

Vasodilator effect of pituitary adenylate cyclase activating polypeptide (PACAP) on femoral blood flow in dogs.

S Naruse1, T Suzuki, T Ozaki, K Nokihara.   

Abstract

The effect of PACAP, a new VIP-like neuropeptide, on femoral arterial blood flow was studied in anesthetized beagle dogs. Intra-arterial infusion of PACAP38, PACAP27, or VIP (0.25-25 pmol/kg) induced a dose-related increase in femoral blood flow. The dose-response curve for PACAP27 or PACAP38 was similar to that for VIP, but the response to PACAP38 at 25 pmol/kg was significantly less than the others. The vasodilator effect of PACAP38, however, lasted three to four times longer than that of PACAP27 or VIP. Vascular effects of PACAP38 and PACAP38(COOH) did not differ. PACAP(1-15), PACAP(10-20), PACAP(27-38), and PACAP(27-38)NH2 had little effect on blood flow. Thus, PACAP38 and PACAP27 are potent VIP-like vasodilators of the femoral arterial bed in dogs; PACAP38, but not PACAP27, differs from VIP in its prolonged vasodilator effect.

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Year:  1993        PMID： 8101368     DOI： 10.1016/0196-9781(93)90139-8

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  9 in total

1.  PACAP immunoreactivity in human malignant tumor samples and cardiac diseases.

Authors:  Z Szanto; Zs Sarszegi; D Reglodi; J Nemeth; K Szabadfi; P Kiss; A Varga; E Banki; K Csanaky; B Gaszner; O Pinter; Zs Szalai; A Tamas
Journal:  J Mol Neurosci       Date:  2012-05-31       Impact factor: 3.444

2.  Expression of pituitary adenylate cyclase-activating polypeptide in the primary lymphoid organs of the duck Anas platyrhynchos.

Authors:  Caterina Squillacioti; Nicola Mirabella; Adriana De Luca; Giuseppe Paino
Journal:  J Anat       Date:  2006-07       Impact factor: 2.610

3.  Central administration of PACAP stimulates gastric secretion mediated through the vagal pathway in anesthetized rats.

Authors:  M Ozawa; M Aono; K Mizuta; M Moriga; M Okuma
Journal:  Dig Dis Sci       Date:  1997-12       Impact factor: 3.199

4.  Possible key residues that determine left gastric artery blood flow response to PACAP in dogs.

Authors:  Mu-Xin Wei; Ping Hu; Ping Wang; Satoru Naruse; Kiyoshi Nokihara; Victor Wray; Tsuyoshi Ozaki
Journal:  World J Gastroenterol       Date:  2010-10-14       Impact factor: 5.742

5.  Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

Authors:  Hirokazu Ohtaki; Tomoya Nakamachi; Kenji Dohi; Yoichi Aizawa; Atsushi Takaki; Kei Hodoyama; Sachiko Yofu; Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba; Manfred Kopf; Yoichiro Iwakura; Kouhei Matsuda; Akira Arimura; Seiji Shioda
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-01       Impact factor: 11.205

6.  Pituitary adenylate cyclase-activating polypeptide (PACAP) induces relaxations of peripheral and cerebral arteries, which are differentially impaired by aging.

Authors:  Zoltan Vamos; Ivan Ivic; Peter Cseplo; Gabor Toth; Andrea Tamas; Dora Reglodi; Akos Koller
Journal:  J Mol Neurosci       Date:  2014-06-19       Impact factor: 3.444

7.  Effects of neuropeptide Y and vasoactive intestinal peptide on human venous smooth muscle in vivo.

Authors:  M Wolzt; W Gerschlager; B Zweytick; B Jilma; H Riemer; K Sertl; H G Eichler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-08       Impact factor: 3.000

8.  Pituitary adenylate cyclase-activating polypeptide, helospectin, and vasoactive intestinal polypeptide in human corpus cavernosum.

Authors:  P Hedlund; P Alm; P Ekström; J Fahrenkrug; J Hannibal; H Hedlund; B Larsson; K E Andersson
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

Review 9.  PACAP and its role in primary headaches.

Authors:  Lars Edvinsson; János Tajti; Levente Szalárdy; László Vécsei
Journal:  J Headache Pain       Date:  2018-03-09       Impact factor: 7.277
  9 in total

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