Literature DB >> 8101231

Molecular cloning of infectious ecotropic murine leukemia virus AK7 from an emv-14-positive AKXL-5 mouse and the resistance of AK7 to recognition by cytotoxic T lymphocytes.

H D White1, W R Green, N R Giné.   

Abstract

The AKXL-5 recombinant inbred mouse strain is positive for the endogenous ecotropic murine leukemia virus emv-14, the only emv present in its germ line. emv-14 is of particular interest because spleen cells expressing emv-14 virus escape recognition by anti-AKR/Gross virus-specific cytotoxic T lymphocytes. We report here the isolation and characterization of a replication-competent emv clone, pAK7, derived from an AKXL-5 mouse. This clone is novel in that it encodes a variant ecotropic murine leukemia virus that, when expressed in SC.Kb target cells, fails to be recognized efficiently by anti-AKR/Gross virus cytotoxic T lymphocytes. The pAK7 clone can therefore be used to further probe mechanisms of escape from cell-mediated immunity.

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Year:  1993        PMID： 8101231      PMCID： PMC237895     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  36 in total

1.  Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas.

Authors:  S K Chattopadhyay; M W Cloyd; D L Linemeyer; M R Lander; E Rands; D R Lowy
Journal:  Nature       Date:  1982-01-07       Impact factor: 49.962

2.  Origin of mink cytopathic focus-forming (MCF) viruses:comparison with ecotropic and xenotropic murine leukemia virus genomes.

Authors:  S K Chattopadhyay; M R Lander; S Gupta; E Rands; D R Lowy
Journal:  Virology       Date:  1981-09       Impact factor: 3.616

3.  Restriction endonuclease mapping of ecotropic murine leukemia viral DNAs: size and sequence heterogeneity of the long terminal repeat.

Authors:  E Rands; D R Lowy; M R Lander; S K Chattopadhyay
Journal:  Virology       Date:  1981-01-30       Impact factor: 3.616

4.  Monoclonal antibodies to xenotropic and MCF murine leukemia viruses derived during the graft-versus-host reaction.

Authors:  J L Portis; F J McAtee; M W Cloyd
Journal:  Virology       Date:  1982-04-15       Impact factor: 3.616

5.  Continuing germ line integration of AKV proviruses during the breeding of AKR mice and derivative recombinant inbred strains.

Authors:  D L Steffen; B A Taylor; R A Weinberg
Journal:  J Virol       Date:  1982-04       Impact factor: 5.103

6.  Internal organization of endogenous proviral DNAs of xenotropic murine leukemia viruses.

Authors:  M D Hoggan; C E Buckler; J F Sears; H W Chan; W P Rowe; M A Martin
Journal:  J Virol       Date:  1982-07       Impact factor: 5.103

7.  The specificity of H-2-restricted cytotoxic T lymphocytes directed to AKR/Gross leukemia virus-induced tumors. I. Isolation of a selectively resistant variant tumor subclone.

Authors:  W R Green
Journal:  Eur J Immunol       Date:  1983-11       Impact factor: 5.532

8.  New class of leukemogenic ecotropic recombinant murine leukemia virus isolated from radiation-induced thymomas of C57BL/6 mice.

Authors:  E Rassart; P Sankar-Mistry; G Lemay; L DesGroseillers; P Jolicoeur
Journal:  J Virol       Date:  1983-02       Impact factor: 5.103

9.  Activation of nonexpressed endogenous ecotropic murine leukemia virus by transfection of genomic DNA into embryo cells.

Authors:  J McCubrey; R Risser
Journal:  J Virol       Date:  1983-03       Impact factor: 5.103

10.  Characterization of monoclonal antibodies reactive with murine leukemia viruses: use in analysis of strains of friend MCF and Friend ecotropic murine leukemia virus.

Authors:  B Chesebro; W Britt; L Evans; K Wehrly; J Nishio; M Cloyd
Journal:  Virology       Date:  1983-05       Impact factor: 3.616
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