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Literature DB >> 810095

Lymphocyte response to hepatitis B surface antigen. Findings in hepatitis and Indian childhood cirrhosis.

Abstract

The lymphocyte delayed hypersensitivity response to phytohaemagglutinin (PHA) and hepatitis B antigen (HBsAG) was evaluated by two in vitro tests-leucocyte migration inhibition and DNA synthesis. Patients convalescing from HBsAG-positive hepatits showed the presence of a state of cell-mediated immune responsiveness to the antigen. In Indian childhood cirrhosis, there was a failure of response to HBsAG and a slight but significant depression of reaction to PHA. It is suggested that the lack of immune reactivity to HBsAG, perhaps determined genetically, may be a significant factor in the evolution of cirrhosis in Indian children.

Entities: Disease Species

Mesh：

Substances：

Year: 1975 PMID： 810095 PMCID： PMC1544585 DOI： 10.1136/adc.50.7.559

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

12 in total

1. Indian childhood cirrhosis.

Authors: S T ACHAR; V B RAJU; S SRIRAMACHARI
Journal: J Pediatr Date: 1960-11 Impact factor: 4.406

2. Dissociation of delayed-hypersensitivy and antibody-synthesising capacities in man. Report of two sibships with thymic dysplasia, lymphoid tissue depletion, and normal immunoglobulins.

Authors: V A Fulginiti; W E Hathaway; D S Pearlman; W R Blackburn; C W Reiquam; J H Githens; H N Claman; C H Kempe
Journal: Lancet Date: 1966-07-02 Impact factor: 79.321

Lymphocyte response to hepatitis B surface antigen. Findings in hepatitis and Indian childhood cirrhosis.

1. Indian childhood cirrhosis.

2. Dissociation of delayed-hypersensitivy and antibody-synthesising capacities in man. Report of two sibships with thymic dysplasia, lymphoid tissue depletion, and normal immunoglobulins.

3. Indian childhood cirrhosis.

4. Lymphocyte transformation by Australia antigen.

5. Immunological picture in Indian childhood cirrhosis.

6. Studies on delayed hypersensitivity to hepatitis B antigen in chimpanzees.

7. An epidemiologic approach to Indian childhood cirrhosis.

Review 8. A leucocyte migration technique for in vitro detection of cellular (delayed type) hypersensitivity in man.

9. Hepatitis-associated antigen and depressed cellular immunity in Indian childhood cirrhosis.

10. Dermatoglyphics in Indian childhood cirrhosis.

1. Indian childhood cirrhosis. A critical review of epidemiological and aetiological factors.

2. Hepatitis B surface antigen (HBsAg) in Indian childhood cirrhosis and viral hepatitis.

3. Indian childhood cirrhosis: a critique of recent observations.