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Literature DB >> 8100656

Immunohistochemical study of neu protein overexpression in clinging in situ duct carcinoma of the breast.

C R De Potter¹, M P Foschini, A M Schelfhout, C A Schroeter, V Eusebi.

Abstract

The expression of neu protein in 26 cases of clinging carcinoma (CC) of the breast was investigated. A distinction is made between two types of CC: one with pleomorphic nuclei (PN) and the other with monomorphic nuclei (MN). The PN type of CC overexpresses the neu protein in almost all cases (85.7%), its cells generally exhibit abundant cytoplasm and intraluminal necrosis is frequently observed. The MN type of CC does not overexpress the neu protein, exhibits bland cytological features and shows no necrosis. It is suggested that CC with PN is related to comedo-type carcinoma, while CC with MN is the forerunner of cribriform carcinoma in situ.

Entities: Disease Gene

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Year: 1993 PMID： 8100656 DOI： 10.1007/bf01605456

Source DB: PubMed Journal: Virchows Arch A Pathol Anat Histopathol ISSN： 0174-7398

9 in total

Review 1. Progress in molecular biology of breast cancer.

Authors: W J Mooi; J L Peterse
Journal: Eur J Cancer Date: 1992 Impact factor: 9.162

2. Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.

Authors: M J van de Vijver; J L Peterse; W J Mooi; P Wisman; J Lomans; O Dalesio; R Nusse
Journal: N Engl J Med Date: 1988-11-10 Impact factor: 91.245

3. The subcellular localization of the neu protein in human normal and neoplastic cells.

Authors: C R De Potter; J Quatacker; G Maertens; S Van Daele; C Pauwels; C Verhofstede; W Eechaute; H Roels
Journal: Int J Cancer Date: 1989-12-15 Impact factor: 7.396

4. The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues.

Authors: C R De Potter; S Van Daele; M J Van de Vijver; C Pauwels; G Maertens; J De Boever; D Vandekerckhove; H Roels
Journal: Histopathology Date: 1989-10 Impact factor: 5.087

5. Long-term follow-up of in situ carcinoma of the breast with special emphasis on clinging carcinoma.

Authors: V Eusebi; M P Foschini; M G Cook; F Berrino; J G Azzopardi
Journal: Semin Diagn Pathol Date: 1989-05 Impact factor: 3.464

6. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.

Authors: D J Slamon; G M Clark; S G Wong; W J Levin; A Ullrich; W L McGuire
Journal: Science Date: 1987-01-09 Impact factor: 47.728

7. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

Authors: L Coussens; T L Yang-Feng; Y C Liao; E Chen; A Gray; J McGrath; P H Seeburg; T A Libermann; J Schlessinger; U Francke
Journal: Science Date: 1985-12-06 Impact factor: 47.728

8. Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ.

Authors: J Bartkova; D M Barnes; R R Millis; W J Gullick
Journal: Hum Pathol Date: 1990-11 Impact factor: 3.466

9. c-erbB-2 expression in benign and malignant breast disease.

Authors: B A Gusterson; L G Machin; W J Gullick; N M Gibbs; T J Powles; C Elliott; S Ashley; P Monaghan; S Harrison
Journal: Br J Cancer Date: 1988-10 Impact factor: 7.640

9 in total

6 in total

Immunohistochemical study of neu protein overexpression in clinging in situ duct carcinoma of the breast.

Review 1. Progress in molecular biology of breast cancer.

2. Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.

3. The subcellular localization of the neu protein in human normal and neoplastic cells.

4. The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues.

5. Long-term follow-up of in situ carcinoma of the breast with special emphasis on clinging carcinoma.

6. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.

7. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

8. Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ.

9. c-erbB-2 expression in benign and malignant breast disease.

Review 1. Are columnar cell lesions the earliest histologically detectable non-obligate precursor of breast cancer?

2. [Flat epithelial neoplasia and other columnar cell lesions of the breast].

3. Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast.

Review 4. Biological features of premalignant disease in the human breast.

5. The p185erbB2 protein is localized on cell organelles involved in cell motility.

Review 6. Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?