Literature DB >> 8100442

Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.

A Katagiri1, Y Tomita, T Nishiyama, M Kimura, S Sato.   

Abstract

P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours, which are more refractory than seminomas to anti-cancer chemotherapy, frequently expressed Pgp and GSTP1-1. Western blot analysis demonstrated lower amount of GSTP1-1 in seminoma than in teratoma. These results suggest that Pgp and GSTP1-1 might contribute to drug resistance in testis cancers.

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Year:  1993        PMID： 8100442      PMCID： PMC1968284          DOI： 10.1038/bjc.1993.299

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  24 in total

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1.  Ultrastructural localization of glutathione S-transferase-pi in human colorectal cancer cells.

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Authors:  Eleni Gaitanarou; Eleni Seretis; Dimitrios Xinopoulos; Emmanuel Paraskevas; Niki Arnoyiannaki; Irene Voloudakis-Baltatzis
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9.  E-cadherin expression in renal cell cancer and its significance in metastasis and survival.

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Journal:  Br J Cancer       Date:  2003-03-24       Impact factor: 7.640
  10 in total

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