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Literature DB >> 8100192

Improved visualization of carcinoid liver metastases by indium-111 pentetreotide scintigraphy following treatment with cold somatostatin analogue.

U Dörr¹, U Räth, M L Sautter-Bihl, G Guzman, D Bach, H J Adrian, H Bihl.

Abstract

Five patients with hepatic metastases of midgut carcinoid underwent somatostatin receptor scintigraphy with indium-111 pentetreotide before and during treatment with octreotide. Octreotide treatment changed the biodistribution of 111In-pentetreotide significantly. Whereas the radioactivity in liver, spleen and kidney decreased, hepatic metastases showed increased contrast. In one patient, liver metastases could only be detected during octreotide treatment. These data suggest that the diagnostic reliability of somatostatin receptor scintigraphy in carcinoid liver metastases is not necessarily compromised by octreotide therapy. Because of different biodistributions, the detection of liver metastases may even be improved during octreotide therapy.

Entities: Chemical Disease Species

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Year: 1993 PMID： 8100192 DOI： 10.1007/bf00209003

Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997

5 in total

Review 1. The role of somatostatin and its analogs in the diagnosis and treatment of tumors.

Authors: S W Lamberts; E P Krenning; J C Reubi
Journal: Endocr Rev Date: 1991-11 Impact factor: 19.871

2. Treatment with Sandostatin and in vivo localization of tumors with radiolabeled somatostatin analogs.

Authors: S W Lamberts; W H Bakker; J C Reubi; E P Krenning
Journal: Metabolism Date: 1990-09 Impact factor: 8.694

3. Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: consequences with regard to diagnosis, localization, and therapy.

Authors: S W Lamberts; L J Hofland; P M van Koetsveld; J C Reubi; H A Bruining; W H Bakker; E P Krenning
Journal: J Clin Endocrinol Metab Date: 1990-09 Impact factor: 5.958

4. In vivo application of [111In-DTPA-D-Phe1]-octreotide for detection of somatostatin receptor-positive tumors in rats.

Authors: W H Bakker; E P Krenning; J C Reubi; W A Breeman; B Setyono-Han; M de Jong; P P Kooij; C Bruns; P M van Hagen; P Marbach
Journal: Life Sci Date: 1991 Impact factor: 5.037

5. [Somatostatin receptor scintigraphy. A new imaging procedure for the specific demonstration of carcinoids of the small intestine].

Authors: U Dörr; U Räth; G Schürmann; E Höring; D Bach; K Wurm; M Scholz; H J Adrian; H Bihl
Journal: Rofo Date: 1993-01

5 in total

7 in total

1. Influence of lanreotide on uptake of ⁶⁸Ga-DOTATATE in patients with neuroendocrine tumours: a prospective intra-patient evaluation.

Authors: E A Aalbersberg; B J de Wit-van der Veen; M W J Versleijen; L J Saveur; G D Valk; M E T Tesselaar; M P M Stokkel
Journal: Eur J Nucl Med Mol Imaging Date: 2018-08-10 Impact factor: 9.236

7. Does PRRT with standard activities of 177Lu-octreotate really achieve relevant somatostatin receptor saturation in target tumor lesions?: insights from intra-therapeutic receptor imaging in patients with metastatic gastroenteropancreatic neuroendocrine tumors.

Authors: Amir Sabet; James Nagarajah; Ahmet Semih Dogan; Hans-Jürgen Biersack; Amin Sabet; Stefan Guhlke; Samer Ezziddin
Journal: EJNMMI Res Date: 2013-12-26 Impact factor: 3.138

7 in total

Improved visualization of carcinoid liver metastases by indium-111 pentetreotide scintigraphy following treatment with cold somatostatin analogue.

Review 1. The role of somatostatin and its analogs in the diagnosis and treatment of tumors.

2. Treatment with Sandostatin and in vivo localization of tumors with radiolabeled somatostatin analogs.

3. Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: consequences with regard to diagnosis, localization, and therapy.

4. In vivo application of [111In-DTPA-D-Phe1]-octreotide for detection of somatostatin receptor-positive tumors in rats.

5. [Somatostatin receptor scintigraphy. A new imaging procedure for the specific demonstration of carcinoids of the small intestine].

1. Influence of lanreotide on uptake of ⁶⁸Ga-DOTATATE in patients with neuroendocrine tumours: a prospective intra-patient evaluation.

Review 2. Drug interactions with radiopharmaceuticals.

Review 3. Molecular imaging of neuroendocrine tumors.

4. Iodine-131 labelled octreotide: not an option for somatostatin receptor therapy.

Review 5. Metaiodobenzylguanidine and somatostatin in oncology: role in the management of neural crest tumours.

6. Somatostatin receptor subtype 2-mediated uptake of radiolabelled somatostatin analogues in the human kidney.

7. Does PRRT with standard activities of 177Lu-octreotate really achieve relevant somatostatin receptor saturation in target tumor lesions?: insights from intra-therapeutic receptor imaging in patients with metastatic gastroenteropancreatic neuroendocrine tumors.