Literature DB >> 8100053

Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase.

A Hashimoto1, T Nishikawa, R Konno, A Niwa, Y Yasumura, T Oka, K Takahashi.   

Abstract

We have examined whether D-amino acid oxidase (DAO) regulates free D-serine content using mutant ddY/DAO- mice lacking DAO activity. We find that the content of D-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral D-serine level is observed between the two strains. These results suggest that, although DAO may participate in the catabolism of D-serine in the cerebellum and periphery, there appears to be other mechanisms for catabolism of endogenous D-serine in the brain.

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Year:  1993        PMID： 8100053     DOI： 10.1016/0304-3940(93)90476-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  40 in total

1.  D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.

Authors:  Jin-Miao Lu; Nian Gong; Yan-Chao Wang; Yong-Xiang Wang
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

2.  Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

Authors:  Jesse Alt; Camilo Rojas; Krystyna Wozniak; Ying Wu; Dana Ferraris; Takashi Tsukamoto; Barbara Slusher
Journal:  Anal Biochem       Date:  2011-08-16       Impact factor: 3.365

3.  D-Serine Signaling and NMDAR-Mediated Synaptic Plasticity Are Regulated by System A-Type of Glutamine/D-Serine Dual Transporters.

Authors:  Oded Bodner; Inna Radzishevsky; Veronika N Foltyn; Ayelet Touitou; Alec C Valenta; Igor F Rangel; Rogerio Panizzutti; Robert T Kennedy; Jean Marie Billard; Herman Wolosker
Journal:  J Neurosci       Date:  2020-07-13       Impact factor: 6.167

4.  A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the Aplysia californica central nervous system.

Authors:  Liping Wang; Nobutoshi Ota; Elena V Romanova; Jonathan V Sweedler
Journal:  J Biol Chem       Date:  2011-02-22       Impact factor: 5.157

Review 5.  D-amino acids as putative neurotransmitters: focus on D-serine.

Authors:  S H Snyder; P M Kim
Journal:  Neurochem Res       Date:  2000-05       Impact factor: 3.996

6.  Inhibition of D-amino-Acid oxidase activity induces pain relief in mice.

Authors:  Wenjuan Zhao; Ryuichi Konno; Xiang-Jun Zhou; Ming Yin; Yong-Xiang Wang
Journal:  Cell Mol Neurobiol       Date:  2007-09-15       Impact factor: 5.046

7.  C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal.

Authors:  L Amery; C Brees; M Baes; C Setoyama; R Miura; G P Mannaerts; P P Van Veldhoven
Journal:  Biochem J       Date:  1998-12-01       Impact factor: 3.857

8.  The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.

Authors:  Sean M Smith; Jason M Uslaner; Peter H Hutson
Journal:  Open Med Chem J       Date:  2010-05-27

Review 9.  The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.

Authors:  L Verrall; P W J Burnet; J F Betts; P J Harrison
Journal:  Mol Psychiatry       Date:  2009-09-29       Impact factor: 15.992

10.  A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.

Authors:  Norihiro Shibuya; Shin Koike; Makiko Tanaka; Mari Ishigami-Yuasa; Yuka Kimura; Yuki Ogasawara; Kiyoshi Fukui; Noriyuki Nagahara; Hideo Kimura
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
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