J E Wagner1. 1. Department of Pediatrics (Divisions of Hematology/Oncology and Bone Marrow Transplantation, University of Minnesota School of Medicine, Minneapolis.
Abstract
PURPOSE: Human umbilical cord blood is a new source of hematopoietic stem cells. PATIENTS AND METHODS: On the basis of prior laboratory investigations in an animal model and subsequent in vitro studies of human hematopoietic progenitors, umbilical cord blood was used to reconstitute hematopoiesis in a patient with Fanconi anemia in 1988. As a result of this first success, umbilical cord blood has been used in the treatment of 15 children with a variety of malignant and nonmalignant diseases, including acute and chronic leukemia, lymphoma, neuroblastoma, Fanconi anemia, aplastic anemia, Hunter syndrome, and congenital immunodeficiency. RESULTS AND CONCLUSIONS: This review summarizes the brief history and potential future applications of cord blood stem cells (CBSCs) in transplantation.
PURPOSE:Human umbilical cord blood is a new source of hematopoietic stem cells. PATIENTS AND METHODS: On the basis of prior laboratory investigations in an animal model and subsequent in vitro studies of human hematopoietic progenitors, umbilical cord blood was used to reconstitute hematopoiesis in a patient with Fanconi anemia in 1988. As a result of this first success, umbilical cord blood has been used in the treatment of 15 children with a variety of malignant and nonmalignant diseases, including acute and chronic leukemia, lymphoma, neuroblastoma, Fanconi anemia, aplastic anemia, Hunter syndrome, and congenital immunodeficiency. RESULTS AND CONCLUSIONS: This review summarizes the brief history and potential future applications of cord blood stem cells (CBSCs) in transplantation.
Authors: Nikolaos G Grigoriadis; Ioannis G Grigoriadis; Sofia Markoula; Minas Paschopoulos; Konstantinos Zikopoulos; Panagiotis Gr Apostolakopoulos; Ioannis S Vizirianakis; Ioannis Georgiou Journal: Am J Stem Cells Date: 2016-05-15
Authors: Simon N Robinson; Paul J Simmons; Hong Yang; Amin M Alousi; J Marcos de Lima; Elizabeth J Shpall Journal: Best Pract Res Clin Haematol Date: 2011-02-23 Impact factor: 3.020