Literature DB >> 8098450

Effect of oesophageal acid instillation on coronary blood flow.

A Chauhan1, M C Petch, P M Schofield.   

Abstract

To assess whether gastrointestinal factors can cause chest pain ("linked angina"), we studied the effect of oesophageal stimulation with acid on coronary blood flow in 20 syndrome X patients. Coronary blood flow velocity (CBFV) was measured with an intracoronary doppler catheter positioned in the proximal left anterior descending coronary artery. Acid stimulation produced typical anginal pain in 11 patients. Mean CBFV was significantly reduced from 7.3 (SD 4.0) to 4.4 (2.8) cm/s. Gastro-oesophageal reflux leading to reduced coronary blood flow may be a mechanism to explain linked angina.

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Mesh：

Year:  1993        PMID： 8098450     DOI： 10.1016/0140-6736(93)90817-z

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  12 in total

1.  Coronary flow reserve and oesophageal dysfunction in syndrome X.

Authors:  A Chauhan; P A Mullins; R Gill; G Taylor; M C Petch; P M Schofield
Journal:  Postgrad Med J       Date:  1996-02       Impact factor: 2.401

2.  Oesophageal sensation assessed by electrical stimuli and brain evoked potentials--a new model for visceral nociception.

Authors:  O Frøbert; L Arendt-Nielsen; P Bak; P Funch-Jensen; J P Bagger
Journal:  Gut       Date:  1995-11       Impact factor: 23.059

3.  Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses.

Authors:  H Yang; S E Plevy; K Taylor; D Tyan; N Fischel-Ghodsian; C McElree; S R Targan; J I Rotter
Journal:  Gut       Date:  1999-04       Impact factor: 23.059

Review 4.  The frontiers of reflux disease.

Authors:  Nimish Vakil
Journal:  Dig Dis Sci       Date:  2006-09-29       Impact factor: 3.199

Review 5.  [Significance of esophagocardiac reflexes for inducing thoracic pain].

Authors:  G Holtmann; P Schlömer; G Gerken
Journal:  Herz       Date:  1999-04       Impact factor: 1.443

Review 6.  Visceral chest pain in unstable angina pectoris and effects of transcutaneous electrical nerve stimulation. (TENS). A review.

Authors:  M Börjesson
Journal:  Herz       Date:  1999-04       Impact factor: 1.443

7.  Pain perception and brain evoked potentials in patients with angina despite normal coronary angiograms.

Authors:  O Frøbert; L Arendt-Nielsen; P Bak; P Funch-Jensen; J Peder Bagger
Journal:  Heart       Date:  1996-05       Impact factor: 5.994

8.  EMERGING THERAPIES AND NOVEL APPROACHES TO VISCERAL PAIN.

Authors:  Ursula Wesselmann; Andrew P Baranowski; Mats Börjesson; Natasha C Curran; Peter P Czakanski; Maria Adele Giamberardino; Timothy J Ness; Meredith T Robbins; Richard J Traub
Journal:  Drug Discov Today Ther Strateg       Date:  2009

Review 9.  Syndrome X--angina and normal coronary angiography.

Authors:  A Chauhan
Journal:  Postgrad Med J       Date:  1995-06       Impact factor: 2.401

10.  Cross-organ sensitization of thoracic spinal neurons receiving noxious cardiac input in rats with gastroesophageal reflux.

Authors:  Chao Qin; Anna P Malykhina; Ann M Thompson; Jay P Farber; Robert D Foreman
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-04-08       Impact factor: 4.052
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