Literature DB >> 8098331

Proliferating cell nuclear antigen (PCNA) in medullary thyroid carcinoma.

A Skopelitou1, P Korkolopoulou, A Papanikolaou, M Hadjiyannakis.   

Abstract

We investigated the expression of proliferating cell nuclear antigen (PCNA) in paraffin sections from 20 cases of medullary thyroid carcinoma (MTC). Follow-up data were available in eleven cases. PCNA index positively correlated with the degree of cellular pleomorphism (grade) of the tumor (p < 0.01), the pathologic stage (p < 0.01) and the poor clinical outcome (p < 0.05). These findings suggest that PCNA may be of prognostic significance in MTC.

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Year:  1993        PMID： 8098331     DOI： 10.1007/bf01218417

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  9 in total

1.  Prognostic factors in medullary thyroid carcinomas. Survival in relation to age, sex, stage, histology, immunocytochemistry, and DNA content.

Authors:  S Schröder; W Böcker; H Baisch; C G Bürk; H Arps; I Meiners; H Kastendieck; P U Heitz; G Klöppel
Journal:  Cancer       Date:  1988-02-15       Impact factor: 6.860

2.  Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase.

Authors:  J E Celis; A Celis
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

3.  The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis.

Authors:  A L Woods; P A Hall; N A Shepherd; A M Hanby; N H Waseem; D P Lane; D A Levison
Journal:  Histopathology       Date:  1991-07       Impact factor: 5.087

4.  Prognostic value of proliferating cell nuclear antigen in gastric carcinoma.

Authors:  S Jain; M I Filipe; P A Hall; N Waseem; D P Lane; D A Levison
Journal:  J Clin Pathol       Date:  1991-08       Impact factor: 3.411

5.  The significance of mitotic rate: a retrospective study of 127 thyroid carcinomas.

Authors:  T K Lee; R T Myers; R B Marshall; M G Bond; B Kardon
Journal:  Hum Pathol       Date:  1985-10       Impact factor: 3.466

6.  Medullary carcinoma of the thyroid in the multiple endocrine neoplasia IIA syndrome.

Authors:  S H Bigner; E B Cox; G Mendelsohn; S B Baylin; S A Wells; J C Eggleston
Journal:  Am J Surg Pathol       Date:  1981-07       Impact factor: 6.394

7.  Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms.

Authors:  P A Hall; D A Levison; A L Woods; C C Yu; D B Kellock; J A Watkins; D M Barnes; C E Gillett; R Camplejohn; R Dover
Journal:  J Pathol       Date:  1990-12       Impact factor: 7.996

8.  The prognostic value of calcitonin immunostaining in medullary carcinoma of the thyroid.

Authors:  M F Saad; N G Ordonez; J J Guido; N A Samaan
Journal:  J Clin Endocrinol Metab       Date:  1984-11       Impact factor: 5.958

9.  Medullary thyroid cancer. An immunohistochemical and humoral study using six separate antigens.

Authors:  F Pacini; F Basolo; R Elisei; L Fugazzola; A Cola; A Pinchera
Journal:  Am J Clin Pathol       Date:  1991-03       Impact factor: 2.493
  9 in total
  3 in total

1.  Proliferation Markers and Their Uses in the Study of Endocrine Tumors.

Authors:  Giuseppe Pelosi; Giuseppe Zamboni
Journal:  Endocr Pathol       Date:  1996       Impact factor: 3.943

2.  Assessment of proliferating-cell nuclear antigen immunostaining in soft-tissue tumours: relationship to histological grade and mitotic activity.

Authors:  P Korkolopoulou; P Christodoulou; A Papanikolaou; A Tsenga; E Thomas-Tsagli
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

3.  Grading of medullary thyroid carcinoma on the basis of tumor necrosis and high mitotic rate is an independent predictor of poor outcome.

Authors:  Bayan Alzumaili; Bin Xu; Philip M Spanheimer; R Michael Tuttle; Eric Sherman; Nora Katabi; Snjezana Dogan; Ian Ganly; Brian R Untch; Ronald A Ghossein
Journal:  Mod Pathol       Date:  2020-04-20       Impact factor: 7.842
  3 in total

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