Literature DB >> 8098255

Adenosine inhibits the NMDA receptor-mediated excitatory postsynaptic potential in the hippocampus.

A de Mendonça1, J A Ribeiro.   

Abstract

The effect of the stable adenosine analogue 2-chloroadenosine (CADO) on the component of the field excitatory postsynaptic potential (fepsp) mediated by the N-methyl-D-aspartate (NMDA) type of glutamate receptor was studied in the hippocampal CA1 area of the rat. CADO inhibited the NMDA receptor-mediated component of the fepsp (EC50 = 0.10 +/- 0.02 microM), more efficiently than it inhibited the fepsp (EC50 = 0.40 +/- 0.08 microM). The results suggest that adenosine may modulate phenomena associated with the NMDA receptor, such as synaptic plasticity and excitotoxicity.

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Year:  1993        PMID： 8098255     DOI： 10.1016/0006-8993(93)91007-f

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Reciprocal inhibition of the AMPA and NMDA components of excitatory postsynaptic potentials in field CA1 of the rat hippocampus in vitro.

Authors:  A V Bazhenov; A M Kleshchevnikov
Journal:  Neurosci Behav Physiol       Date:  1999 Nov-Dec

2.  Presynaptic inhibition preferentially reduces in NMDA receptor-mediated component of transmission in rat midbrain dopamine neurons.

Authors:  Y N Wu; K Z Shen; S W Johnson
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

Review 3.  Neuroadaptations in adenosine receptor signaling following long-term ethanol exposure and withdrawal.

Authors:  Tracy R Butler; Mark A Prendergast
Journal:  Alcohol Clin Exp Res       Date:  2011-07-18       Impact factor: 3.455

4.  Effect of allopurinol on hypoxia-induced modification of the NMDA receptor in newborn piglets.

Authors:  P J Marro; C B Andersen; O P Mishra; M Delivoria-Papadopoulos
Journal:  Neurochem Res       Date:  1999-10       Impact factor: 3.996

5.  Behavioural effects of adenosine locally applied into ventral hippocampus of adult male rats.

Authors:  S L Salas; F A Redmond; E O Alvarez
Journal:  J Neural Transm Gen Sect       Date:  1995

6.  Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist.

Authors:  Tracy R Butler; Katherine J Smith; Rachel L Self; Brittany B Braden; Mark A Prendergast
Journal:  Alcohol Clin Exp Res       Date:  2008-07       Impact factor: 3.455

Review 7.  International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.

Authors:  B B Fredholm; A P IJzerman; K A Jacobson; K N Klotz; J Linden
Journal:  Pharmacol Rev       Date:  2001-12       Impact factor: 18.923
  7 in total

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