Literature DB >> 8098250

The molecular basis of the human serum paraoxonase activity polymorphism.

R Humbert1, D A Adler, C M Disteche, C Hassett, C J Omiecinski, C E Furlong.   

Abstract

The organophosphate cholinesterase inhibitor paraoxon is hydrolysed by serum paraoxonase/arylesterase. A genetic polymorphism of paraoxonase (PON) activity which determines high versus low paraoxon hydrolysis in human populations, may determine sensitivity to parathion poisoning. We demonstrate that arginine at position 192 specifies high activity PON whereas a glutamine specifies the low activity variant. Allele-specific probes or restriction enzyme analysis of amplified DNA allow for the genotyping of individuals. PON maps to chromosome 7q21-22, proximal to the cystic fibrosis gene, in agreement with previous genetic linkage studies.

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Year:  1993        PMID： 8098250     DOI： 10.1038/ng0193-73

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  140 in total

1.  A multilocus genotyping assay for candidate markers of cardiovascular disease risk.

Authors:  S Cheng; M A Grow; C Pallaud; W Klitz; H A Erlich; S Visvikis; J J Chen; C R Pullinger; M J Malloy; G Siest; J P Kane
Journal:  Genome Res       Date:  1999-10       Impact factor: 9.043

2.  Polymorphism in high density lipoprotein paraoxonase gene and risk of acute myocardial infarction in men: prospective nested case-control study.

Authors:  J T Salonen; R Malin; T P Tuomainen; K Nyyssönen; T A Lakka; T Lehtimäki
Journal:  BMJ       Date:  1999-08-21

3.  A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.

Authors:  M R Nelson; S L Kardia; R E Ferrell; C F Sing
Journal:  Genome Res       Date:  2001-03       Impact factor: 9.043

4.  Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis.

Authors:  Indranil Banerjee
Journal:  Eur J Epidemiol       Date:  2010-06-09       Impact factor: 8.082

5.  Correlation between PON1 gene polymorphisms and breast cancer risk: a Meta-analysis.

Authors:  Yayuan Wen; Zemin Huang; Xiaohua Zhang; Bo Gao; Yujun He
Journal:  Int J Clin Exp Med       Date:  2015-11-15

Review 6.  Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease.

Authors:  Daniel Seung Kim; Judit Marsillach; Clement E Furlong; Gail P Jarvik
Journal:  Pharmacogenomics       Date:  2013-09       Impact factor: 2.533

7.  Association between activity and genotypes of paraoxonase1 L55M (rs854560) increases the disease activity of rheumatoid arthritis through oxidative stress.

Authors:  Maryam Tanhapour; Shiva Shahmohamadnejad; Asad Vaisi-Raygani; Amir Kiani; Yadola Shakiba; Zohreh Rahimi; Fariborz Bahrehmand; Ebrahim Shakiba; Ali-Akbar Vaisi-Raygani; Reza Alibakhshi; Atefeh Eivazi; Tayebeh Pourmotabbed
Journal:  Mol Biol Rep       Date:  2018-12-01       Impact factor: 2.316

Review 8.  Human PON1, a biomarker of risk of disease and exposure.

Authors:  C E Furlong; S M Suzuki; R C Stevens; J Marsillach; R J Richter; G P Jarvik; H Checkoway; A Samii; L G Costa; A Griffith; J W Roberts; D Yearout; C P Zabetian
Journal:  Chem Biol Interact       Date:  2010-03-23       Impact factor: 5.192

9.  Paraoxonase 1 (PON1) status and substrate hydrolysis.

Authors:  Rebecca J Richter; Gail P Jarvik; Clement E Furlong
Journal:  Toxicol Appl Pharmacol       Date:  2008-11-13       Impact factor: 4.219

10.  Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease.

Authors:  Angelika D Manthripragada; Sadie Costello; Myles G Cockburn; Jeff M Bronstein; Beate Ritz
Journal:  Epidemiology       Date:  2010-01       Impact factor: 4.822
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