Central effects of naloxone and selected opioid agonists on cortisol and prolactin secretion in non-stressed sheep.

1. Intravenous morphine decreases cortisol and increases prolactin concentrations in male sheep whereas naloxone has the opposite effect. 2. In this investigation, the effects of intracerebroventricular injections of naloxone, morphine (mu agonist), dynorphin (kappa agonist) and DADLE (delta/mu agonist) on cortisol and prolactin release were investigated. 3. None of the drugs affected cortisol secretion. 4. Naloxone transiently decreased prolactin levels (P < 0.05). 5. All the opioids tended to enhance prolactin secretion and the highest dose (300 micrograms) of DADLE produced a significant (P < 0.007) sustained increase. 6. These results are consistent with the view that exogenous and endogenous opioids affect the pituitary to influence cortisol release in sheep but act also at the hypothalamic level to influence prolactin secretion.