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Literature DB >> 8097486

Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.

G Giuili¹, N Roechel, U Scholl, M G Mattei, G Guellaen.

Abstract

We have determined the chromosomal location of the human genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S alpha 3 and beta 3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3-4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.

Entities: Gene Species

Mesh：

Substances：
Guanylate Cyclase

Year: 1993 PMID： 8097486 DOI： 10.1007/bf00218267

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

29 in total

1. Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.

Authors: C Harteneck; B Wedel; D Koesling; J Malkewitz; E Böhme; G Schultz
Journal: FEBS Lett Date: 1991-11-04 Impact factor: 4.124

2. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung.

Authors: M Nakane; K Arai; S Saheki; T Kuno; W Buechler; F Murad
Journal: J Biol Chem Date: 1990-10-05 Impact factor: 5.157

3. A new form of guanylyl cyclase is preferentially expressed in rat kidney.

Authors: P S Yuen; L R Potter; D L Garbers
Journal: Biochemistry Date: 1990-12-11 Impact factor: 3.162

4. The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. Homology between the two subunits of the enzyme.

Authors: D Koesling; C Harteneck; P Humbert; A Bosserhoff; R Frank; G Schultz; E Böhme
Journal: FEBS Lett Date: 1990-06-18 Impact factor: 4.124

7. Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor.

Authors: Martín L Marro; Concepción Peiró; Catherine M Panayiotou; Reshma S Baliga; Sabine Meurer; Harald H H W Schmidt; Adrian J Hobbs
Journal: J Biol Chem Date: 2008-05-12 Impact factor: 5.157

7 in total

Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.

1. Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.

2. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung.

3. A new form of guanylyl cyclase is preferentially expressed in rat kidney.

4. The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. Homology between the two subunits of the enzyme.

5. Oxidative-reductive modulation of guinea pig splenic cell guanylate cyclase activity.

6. Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer.

7. Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.

Review 8. Calcium and the mechanism of light adaptation in vertebrate photoreceptors.

9. The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium.

10. The human endonexin II (ENX2) gene is located at 4q28----q32.

1. Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner.

2. Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase.

Review 3. RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase.

4. Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.

5. Genomic organization of alpha1 and beta1 subunits of the mammalian soluble guanylyl cyclase genes.

6. Promoter activity of the 5'-flanking regions of medaka fish soluble guanylate cyclase alpha1 and beta1 subunit genes.

7. Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor.