| Literature DB >> 8097028 |
Abstract
In an attempt to probe the relationship between excitotoxicity and increases in intracellular calcium ([Ca2+]i), BAPTA-AM and its analogs were applied to cultured hippocampal neurons. Chelation of [Ca2+]i depressed and prolonged transient responses to glutamate and did not effect elevation of [Ca2+]i by prolonged exposure. This explains the inability of the chelators to prevent glutamate-induced toxicity.Entities:
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Year: 1993 PMID： 8097028 DOI： 10.1016/0304-3940(93)90518-p
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046