| Literature DB >> 8096488 |
O Koiwai1, Y Yasui, Y Sakai, T Watanabe, K Ishii, S Yanagihara, T Andoh.
Abstract
The mouse cDNA encoding DNA topoisomerase I (TopoI) was cloned and the nucleotide sequence of 3512 bp was determined. The cDNA clone contained an open reading frame encoding a protein of 767 amino acids (aa), which is 2 aa longer than its human counterpart. Overall aa sequence homology between the mouse and human, and between the mouse and yeast (Saccharomyces cerevisiae) sequences was 96% and 42%, respectively. The mouse TopI gene was mapped at position 54.5 on chromosome 2 from linkage analyses of a three-point cross test with Geg, Ada, and a as marker genes.Entities:
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Year: 1993 PMID： 8096488 DOI： 10.1016/0378-1119(93)90331-v
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688