Literature DB >> 8095919

Polymorphic tandem repeat region in interleukin-1 alpha intron 6.

S Bailly1, F S di Giovine, G W Duff.   

Abstract

Analysis of polymerase chain reaction amplified products from the sixth intron of the human interleukin-1 alpha gene reveals a high polymorphism (polymorphism information content = 0.51) in a Caucasian population. Altogether, seven alleles have been defined ranging from 620 to 1220bp. This polymorphism is probably attributable to a variable number of 46-bp tandem repeats, each containing potential regulatory sequences.

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Year:  1993        PMID： 8095919     DOI： 10.1007/bf00230231

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  5 in total

1.  PCR amplification of long DNA fragments.

Authors:  M R Ponce; J L Micol
Journal:  Nucleic Acids Res       Date:  1992-02-11       Impact factor: 16.971

2.  The human interleukin-1 alpha gene is located on the long arm of chromosome 2 at band q13.

Authors:  M Lafage; N Maroc; P Dubreuil; R de Waal Malefijt; M J Pébusque; Y Carcassonne; P Mannoni
Journal:  Blood       Date:  1989-01       Impact factor: 22.113

3.  Interleukin-1 alpha gene intron containing variable repeat region coding for the SP1 transcription factor recognition sequence is polymorphic.

Authors:  A Haugen; D Mann; C Murray; A Weston; J C Willey
Journal:  Mol Carcinog       Date:  1989       Impact factor: 4.784

4.  Plasma levels of interleukin-1-alpha in rheumatoid arthritis.

Authors:  J A Eastgate; J A Symons; N C Wood; S J Capper; G W Duff
Journal:  Br J Rheumatol       Date:  1991-08

5.  Complete nucleotide sequence of the gene for human interleukin 1 alpha.

Authors:  Y Furutani; M Notake; T Fukui; M Ohue; H Nomura; M Yamada; S Nakamura
Journal:  Nucleic Acids Res       Date:  1986-04-25       Impact factor: 16.971
  5 in total
  4 in total

1.  Inflammatory bowel disease: definition, epidemiology, etiologic aspects, and immunogenetic studies.

Authors:  Bing Xia; JBA Crusius; SGM Meuwissen; AS Pe?a
Journal:  World J Gastroenterol       Date:  1998-10       Impact factor: 5.742

2.  Predictive value of interleukin 1 gene polymorphisms for surgery.

Authors:  A Crilly; N Maiden; H A Capell; R Madhok
Journal:  Ann Rheum Dis       Date:  2000-09       Impact factor: 19.103

3.  Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals.

Authors:  H Cullup; P G Middleton; G Duggan; J S Conn; A M Dickinson
Journal:  Clin Exp Immunol       Date:  2004-08       Impact factor: 4.330

4.  Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.

Authors:  G Bioque; J B Crusius; I Koutroubakis; G Bouma; P J Kostense; S G Meuwissen; A S Peña
Journal:  Clin Exp Immunol       Date:  1995-11       Impact factor: 4.330
  4 in total

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