Literature DB >> 8095154

T cell antigen receptor immune complexes demonstrating biologic and proteolytic activity.

C L Bristow1, P M Flood.   

Abstract

An elastase-like protease, recently recognized as a specific product of murine T cells, may functionally associate with the classical TCR. T cell elastase, found in combination with the natural elastase inhibitor alpha 1-antitrypsin (alpha 1-protease inhibitor, alpha 1-PI), is produced by both CD4+ and CD8+ T lymphocytes. T cell elastase and alpha 1-PI are found chemically associated with the TCR in an antigen-specific complex reminiscent of the Ig-complement 'immune complexes'.

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Year:  1993        PMID： 8095154     DOI： 10.1093/intimm/5.1.79

Source DB:  PubMed          Journal:  Int Immunol        ISSN： 0953-8178            Impact factor:   4.823


  7 in total

1.  Immunoregulatory activity of a T-cell receptor alpha chain demonstrated by in vitro transcription and translation.

Authors:  T Onda; T Brunner; H Messier; R Bissonnette; F Echeverri; G Baier; A Fotedar; D R Green
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

2.  Self antigen prognostic for human immunodeficiency virus disease progression.

Authors:  C L Bristow; H Patel; R R Arnold
Journal:  Clin Diagn Lab Immunol       Date:  2001-09

3.  α1Proteinase inhibitor regulates CD4+ lymphocyte levels and is rate limiting in HIV-1 disease.

Authors:  Cynthia L Bristow; Mariya A Babayeva; Michelle LaBrunda; Michael P Mullen; Ronald Winston
Journal:  PLoS One       Date:  2012-02-17       Impact factor: 3.240

4.  B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

Authors:  J Lang; M Jackson; L Teyton; A Brunmark; K Kane; D Nemazee
Journal:  J Exp Med       Date:  1996-11-01       Impact factor: 14.307

5.  Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4+ T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis.

Authors:  Cynthia L Bristow; Mary Ann B Reeves; Ronald Winston
Journal:  Front Oncol       Date:  2021-11-25       Impact factor: 6.244

6.  Alphataxin, an Orally Available Small Molecule, Decreases LDL Levels in Mice as a Surrogate for the LDL-Lowering Activity of Alpha-1 Antitrypsin in Humans.

Authors:  Cynthia L Bristow; Ronald Winston
Journal:  Front Pharmacol       Date:  2021-06-09       Impact factor: 5.810

7.  Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls.

Authors:  Cynthia L Bristow; Sara Ferrando-Martinez; Ezequiel Ruiz-Mateos; Manuel Leal; Ronald Winston
Journal:  Front Cell Dev Biol       Date:  2019-11-21
  7 in total

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