Literature DB >> 8094929

Immunization of rabbits with enterotoxigenic E. coli colonization factor antigen (CFA/I) encapsulated in biodegradable microspheres of poly (lactide-co-glycolide).

R Edelman1, R G Russell, G Losonsky, B D Tall, C O Tacket, M M Levine, D H Lewis.   

Abstract

We have searched for an effective oral delivery system for a purified enterotoxigenic Escherichia coli (ETEC) fimbrial adhesin, CFA/I, which elicits anti-colonization immunity. Purified CFA/I antigen encapsulated in biodegradable polymer microspheres of poly (DL-lactide-co-glycolide) (PLG) induced a vigorous, systemic CFA/I IgG antibody response in rabbits immunized once via intragastric tube; oral, unencapsulated CFA/I induced little or no circulating antibody. CFA/I-specific, S-IgA coproantibody was detected in one of three rabbits fed with the CFA/I-PLG microsphere vaccine. We conclude that PLG microspheres protected CFA/I from degradation in the stomach and effectively delivered the antigen for processing by the host's immune system.

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Year:  1993        PMID： 8094929     DOI： 10.1016/0264-410x(93)90012-m

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  15 in total

1.  Orally administered microencapsulated reovirus can bypass suckled, neutralizing maternal antibody that inhibits active immunization of neonates.

Authors:  S B Periwal; T J Speaker; J J Cebra
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

2.  Intestinal absorption of PLAGA microspheres in the rat.

Authors:  C Damgé; M Aprahamian; H Marchais; J P Benoit; M Pinget
Journal:  J Anat       Date:  1996-12       Impact factor: 2.610

3.  Molecular mechanism of Escherichia coli H10407 induced diarrhoea and its control through immunomodulatory action of bioactives from Simarouba amara (Aubl.).

Authors:  Hegde Veena; Sandesh K Gowda; Rajeshwara N Achur; Nayaka Boramuthi Thippeswamy
Journal:  J Microbiol       Date:  2021-02-25       Impact factor: 3.422

4.  Partially assembled K99 fimbriae are required for protection.

Authors:  Miguel A Ascón; Javier Ochoa-Repáraz; Nancy Walters; David W Pascual
Journal:  Infect Immun       Date:  2005-11       Impact factor: 3.441

5.  Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres.

Authors:  R Shahin; M Leef; J Eldridge; M Hudson; R Gilley
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

6.  Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: immunogenicity and efficacy against lethal SEB intoxication in mice.

Authors:  G H Lowell; R W Kaminski; S Grate; R E Hunt; C Charney; S Zimmer; C Colleton
Journal:  Infect Immun       Date:  1996-05       Impact factor: 3.441

7.  Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.

Authors:  Hirenkumar K Makadia; Steven J Siegel
Journal:  Polymers (Basel)       Date:  2011-08-26       Impact factor: 4.329

8.  Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response.

Authors:  D W Pascual; D M Hone; S Hall; F W van Ginkel; M Yamamoto; N Walters; K Fujihashi; R J Powell; S Wu; J L Vancott; H Kiyono; J R McGhee
Journal:  Infect Immun       Date:  1999-12       Impact factor: 3.441

9.  Attenuated Shigella flexneri 2a vaccine strain CVD 1204 expressing colonization factor antigen I and mutant heat-labile enterotoxin of enterotoxigenic Escherichia coli.

Authors:  H Koprowski; M M Levine; R J Anderson; G Losonsky; M Pizza; E M Barry
Journal:  Infect Immun       Date:  2000-09       Impact factor: 3.441

10.  Pathogenicity and immune response measured in mice following intranasal challenge with enterotoxigenic Escherichia coli strains H10407 and B7A.

Authors:  Wyatt Byrd; Steven R Mog; Frederick J Cassels
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441
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