| Literature DB >> 8094456 |
X J Yao1, S Garzon, F Boisvert, W A Haseltine, E A Cohen.
Abstract
To investigate the role of vpu in the cytopathicity of human immunodeficiency type 1 (HIV-1), the MT4 CD4+ T-cell line was infected with viruses that were isogenic except for their ability to produce the vpu protein. The experiments described here demonstrate that expression of vpu reduces HIV-1 cytopathic effects by decreasing the rate of syncytia formation. By reducing the concentration of gp 120 at the cell surface, vpu limits cell killing by syncytia formation.Entities:
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Year: 1993 PMID： 8094456
Source DB: PubMed Journal: J Acquir Immune Defic Syndr (1988) ISSN： 0894-9255