Literature DB >> 8094380

Effect of modulation of polymorphonuclear leukocyte migration with anti-CD18 antibody on pathogenesis of experimental otitis media in guinea pigs.

J Patel1, T Chonmaitree, F Schmalstieg.   

Abstract

Guinea pigs were treated with anti-CD18 antibody (M8), and subsequently middle ears (ME) were infected with nontypeable Haemophilus influenzae. Forty-eight hours after infection, the ME washes of these animals had significantly lower polymorphonuclear leukocyte numbers but higher bacterial counts compared with washes of animals treated with control antibody (M11) or saline. The edema and epithelial damage of ME tissues correlated directly with polymorphonuclear leukocyte numbers and not bacterial counts.

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Year:  1993        PMID： 8094380      PMCID： PMC302850          DOI： 10.1128/iai.61.3.1132-1135.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

Review 1.  The leukocyte integrins.

Authors:  T K Kishimoto; R S Larson; A L Corbi; M L Dustin; D E Staunton; T A Springer
Journal:  Adv Immunol       Date:  1989       Impact factor: 3.543

Review 2.  Leukocyte adherence defect.

Authors:  F C Schmalstieg
Journal:  Pediatr Infect Dis J       Date:  1988-12       Impact factor: 2.129

3.  Arachidonic acid metabolites in otitis media pathogenesis.

Authors:  T T Jung
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1988 May-Jun

4.  Prostaglandins, leukotrienes, and other arachidonic acid metabolites in the pathogenesis of otitis media.

Authors:  T T Jung
Journal:  Laryngoscope       Date:  1988-09       Impact factor: 3.325

5.  Hydrolase activity in acute otitis media with effusion.

Authors:  W F Diven; R H Glew; K L LaMarco
Journal:  Ann Otol Rhinol Laryngol       Date:  1985 Jul-Aug       Impact factor: 1.547

6.  Oxygen consumption of middle ear and peripheral blood neutrophils in acute suppurative otitis media.

Authors:  J M Bernstein; J R Humbert; M M Hliwa
Journal:  Am J Otolaryngol       Date:  1985 May-Jun       Impact factor: 1.808

7.  Chronic middle ear effusions. Immunochemical and bacteriological investigations.

Authors:  Y S Liu; D J Lim; R W Lang; H G Birck
Journal:  Arch Otolaryngol       Date:  1975-05

8.  The bacteriology and cytology of chronic otitis media with effusion.

Authors:  G S Giebink; S K Juhn; M L Weber; C T Le
Journal:  Pediatr Infect Dis       Date:  1982 Mar-Apr

9.  Experimental otitis media in chinchillas.

Authors:  D M Lewis; J L Schram; S J Meadema; D J Lim
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1980 May-Jun

10.  Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes.

Authors:  E I Tuomanen; K Saukkonen; S Sande; C Cioffe; S D Wright
Journal:  J Exp Med       Date:  1989-09-01       Impact factor: 14.307
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  3 in total

1.  Interleukin 8 in middle ear fluid during acute otitis media: correlation with aetiology and bacterial eradication.

Authors:  E Leibovitz; R Dagan; J H Laver; L Piglansky; S Raiz; M R Abboud; D M Fliss; A Leiberman; A Barzilai
Journal:  Arch Dis Child       Date:  2000-02       Impact factor: 3.791

2.  Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrB and rfaD mutants.

Authors:  H H Tong; Y Chen; M James; J Van Deusen; D B Welling; T F DeMaria
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

3.  In vitro regulation of neutrophil migration by beta 2 integrins (LFA-1 and Mac-1) in patients with otitis media.

Authors:  M Kamimura; T Himi; A Kataura
Journal:  Eur Arch Otorhinolaryngol       Date:  1997       Impact factor: 2.503
  3 in total

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