Literature DB >> 8093596

Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens.

H H Samson1, C W Hodge, G A Tolliver, M Haraguchi.   

Abstract

Rats initiated to self-administer 10% ethanol (v/v) in an operant situation using the sucrose-substitution technique received bilateral n. accumbens or caudate nucleus microinjections of d-amphetamine (4, 10, and 20 micrograms/brain), quinpirole (4 micrograms/brain), and/or raclopride (0.1, 0.5, and 1.0 micrograms/brain). Only microinjections into the n. accumbens produced changes in rate and pattern of responding. With d-amphetamine, an increase in total responding and a slowing of initial response rate was seen, whereas with raclopride administration a dose-related decrease in total responding was observed with no alteration in momentary response rates. Drug-dependent behavioral rate and pattern differences suggest that DA activity in the n. accumbens influences ethanol reinforced behavior.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8093596     DOI： 10.1016/0361-9230(93)90049-h

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  42 in total

1.  Effects of chronic alcohol and repeated deprivations on dopamine D1 and D2 receptor levels in the extended amygdala of inbred alcohol-preferring rats.

Authors:  Youssef Sari; Richard L Bell; Feng C Zhou
Journal:  Alcohol Clin Exp Res       Date:  2006-01       Impact factor: 3.455

2.  Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication.

Authors:  Jing Liang; Asha Suryanarayanan; Alana Abriam; Bradley Snyder; Richard W Olsen; Igor Spigelman
Journal:  J Neurosci       Date:  2007-11-07       Impact factor: 6.167

3.  The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.

Authors:  Jason P Schroeder; David H Overstreet; Clyde W Hodge
Journal:  Psychopharmacology (Berl)       Date:  2005-02-17       Impact factor: 4.530

4.  The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

Authors:  Clyde W Hodge; Michael F Miles; Amanda C Sharko; Rebekah A Stevenson; Jennie R Hillmann; Veronique Lepoutre; Joyce Besheer; Jason P Schroeder
Journal:  Psychopharmacology (Berl)       Date:  2005-11-15       Impact factor: 4.530

5.  Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice.

Authors:  Abigail E Agoglia; Amanda C Sharko; Kelly E Psilos; Sarah E Holstein; Grant T Reid; Clyde W Hodge
Journal:  Alcohol Clin Exp Res       Date:  2015-02-19       Impact factor: 3.455

Review 6.  Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior.

Authors:  Eduardo F Gallo
Journal:  Neurochem Int       Date:  2019-02-01       Impact factor: 3.921

7.  Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice.

Authors:  Takashi Okamoto; Mark T Harnett; Hitoshi Morikawa
Journal:  J Neurophysiol       Date:  2005-09-07       Impact factor: 2.714

Review 8.  Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs.

Authors:  Hitoshi Morikawa; Richard A Morrisett
Journal:  Int Rev Neurobiol       Date:  2010       Impact factor: 3.230

9.  Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity.

Authors:  Eric A Engleman; Zheng-Ming Ding; Scott M Oster; Jamie E Toalston; Richard L Bell; James M Murphy; William J McBride; Zachary A Rodd
Journal:  Alcohol Clin Exp Res       Date:  2009-09-17       Impact factor: 3.455

10.  Blockade of GABA(A) receptors within the extended amygdala attenuates D(2) regulation of alcohol-motivated behaviors in the ventral tegmental area of alcohol-preferring (P) rats.

Authors:  William J A Eiler; Harry L June
Journal:  Neuropharmacology       Date:  2007-03-12       Impact factor: 5.250
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.