| Literature DB >> 8092847 |
F Maggiolo1, A Taras, S Frontespezi, M C Legnani, M A Silanos, G Pravettoni, F Suter.
Abstract
The postantibiotic effect (PAE), sub-MIC effect (SME), and postantibiotic sub-MIC effect (PASME) of imipenem on Pseudomonas aeruginosa were investigated with an in vitro dynamic model reproducing in vivo elimination kinetics of the antibiotic. The PASMEs were constantly longer than the corresponding SMEs, but differences between them were not statistically significant. Both PASMEs and SMEs were initially bactericidal and were significantly longer than PAEs. The mean values of both PASMEs and SMEs were over 12 h. SMEs appear to be more relevant for the bacterial growth kinetics than PAEs.Entities:
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Year: 1994 PMID： 8092847 PMCID： PMC188222 DOI： 10.1128/AAC.38.6.1416
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191