The effects of exercise on the oral consumption of morphine and methadone in rats.

Endogenous opioid peptides have been hypothesised to play a regulatory role in exogenous opiate agonist dependence. It was hypothesised that exercised rats would demonstrate increased beta-endorphin (beta EP) levels and decreased exogenous opiate intake. After providing morphine or methadone as their sole liquid, drug preference levels were determined by amounts of exogenous opiate consumed when rats were offered a choice between drugged and nondrugged solutions. Treatment animals were exercised in a treadmill and were found to consume significantly less exogenous opiate than control animals. Plasma, pituitary, and whole brain beta EP levels were nonsignificantly higher in exercised animals. Differences were observed in the drug ingestion patterns of morphine- and methadone-exposed rats.