M H Gold1. 1. Gold Skin Care Center, Nashville, TN 37205.
Abstract
BACKGROUND: Fibrel is a medical implant device that has demonstrated use in the correction of cutaneous depressions from acne scars and wrinkles. OBJECTIVE: Mechanisms of actions have been proposed that have theorized the production of new collagen over time as a result of the Fibrel implant. The present study utilized human volunteers to study the histologic response of Fibrel over time. METHODS: Fibrel was injected into tattoo sites behind the ears of human volunteers; skin biopsies were taken at various time intervals and studied histologically by a clinical pathologist. RESULTS: An overall increase over time was noted with regard to production of collagen and inflammatory response. No change in elastic tissue was found. CONCLUSIONS: Fibrel does promote new collagen synthesis and inflammatory response and thus is useful to correct cutaneous depressions via soft tissue augmentation.
BACKGROUND: Fibrel is a medical implant device that has demonstrated use in the correction of cutaneous depressions from acne scars and wrinkles. OBJECTIVE: Mechanisms of actions have been proposed that have theorized the production of new collagen over time as a result of the Fibrel implant. The present study utilized human volunteers to study the histologic response of Fibrel over time. METHODS: Fibrel was injected into tattoo sites behind the ears of human volunteers; skin biopsies were taken at various time intervals and studied histologically by a clinical pathologist. RESULTS: An overall increase over time was noted with regard to production of collagen and inflammatory response. No change in elastic tissue was found. CONCLUSIONS: Fibrel does promote new collagen synthesis and inflammatory response and thus is useful to correct cutaneous depressions via soft tissue augmentation.
Authors: Hema Sharma Datta; S K Mitra; Rangesh Paramesh; Bhushan Patwardhan Journal: Evid Based Complement Alternat Med Date: 2011-06-08 Impact factor: 2.629