Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cardioinhibitory peptides from Limulus polyphemus: modulation of the neurogenic heart.

Literature DB >> 8089310

Cardioinhibitory peptides from Limulus polyphemus: modulation of the neurogenic heart.

Abstract

Four neuropeptides have been isolated and sequenced from acetone extracts of brains of the horseshoe crab Limulus polyphemus. They belong to a newly discovered peptide family in invertebrates. A possible role of the four peptides from Limulus as cardioregulatory neurotransmitters has been tested on the isolated Limulus heart. Three of the peptides (DEGHKMLYFamide, GHSLLHFamide, and PDHHMMYFamide) produce dose-dependent decreases in both amplitude and rate of the heart contractions, whereas DHGNMLYFamide reduces only the amplitude of the heartbeat. All four peptides differ in threshold, potency and duration of their effects.

Entities: Chemical Species

Mesh：

Substances：

Year: 1994 PMID： 8089310 DOI： 10.1007/bf00354079

Source DB: PubMed Journal: J Comp Physiol B ISSN： 0174-1578 Impact factor: 2.200

Keyword Cloud
References

13 in total

1. Purification of achatin-I from the atria of the African giant snail, Achatina fulica, and its possible function.

Authors: K Fujimoto; I Kubota; Y Yasuda-Kamatani; H Minakata; K Nomoto; M Yoshida; A Harada; Y Muneoka; M Kobayashi
Journal: Biochem Biophys Res Commun Date: 1991-06-14 Impact factor: 3.575

2. THE NATURE OF THE ACTION OF DRUGS ON THE HEART (PRELIMINARY NOTE).

Authors: A J Carlson
Journal: Science Date: 1904-11-18 Impact factor: 47.728

3. Cardioregulation in limulus. II. Gamma aminobutyric acid, antagonists and inhibitor nerves.

Authors: R A Pax; R C Sanborn
Journal: Biol Bull Date: 1967-06 Impact factor: 1.818

4. Cardioregulation in Limulus. 3. Inhibition by 5-hydroxytryptamine and antagonism by bromlysergic acid diethylamide and picrotoxin.

Authors: R A Pax; R C Sanborn
Journal: Biol Bull Date: 1967-06 Impact factor: 1.818

9. The identification and structure-activity relations of a cardioactive FMRFamide-related peptide from the blue crab Callinectes sapidus.

Authors: K G Krajniak
Journal: Peptides Date: 1991 Nov-Dec Impact factor: 3.750

10. Seven FMRFamide-related and two SCP-related cardioactive peptides from Helix.

Authors: D A Price; W Lesser; T D Lee; K E Doble; M J Greenberg
Journal: J Exp Biol Date: 1990-11 Impact factor: 3.312

Cardioinhibitory peptides from Limulus polyphemus: modulation of the neurogenic heart.

1. Purification of achatin-I from the atria of the African giant snail, Achatina fulica, and its possible function.

2. THE NATURE OF THE ACTION OF DRUGS ON THE HEART (PRELIMINARY NOTE).

3. Cardioregulation in limulus. II. Gamma aminobutyric acid, antagonists and inhibitor nerves.

4. Cardioregulation in Limulus. 3. Inhibition by 5-hydroxytryptamine and antagonism by bromlysergic acid diethylamide and picrotoxin.

5. A novel cyclic undercapeptide, WY-40, 770, with prolonged growth hormone release inhibiting activity.

6. Synthesis of peptide amides by Fmoc-solid-phase peptide synthesis and acid labile anchor groups.

7. Amine modulation of the neurogenic Limulus heart.

8. Identification and localization of catecholamines in the nervous system of Limulus polyphemus.

9. The identification and structure-activity relations of a cardioactive FMRFamide-related peptide from the blue crab Callinectes sapidus.

10. Seven FMRFamide-related and two SCP-related cardioactive peptides from Helix.