Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Interferon-alpha inhibits murine macrophage transforming growth factor-beta mRNA expression.

Literature DB >> 8088926

Interferon-alpha inhibits murine macrophage transforming growth factor-beta mRNA expression.

S Dhanani¹, M Huang, J Wang, S M Dubinett.

Abstract

Transforming growth factor-beta (TGF-beta), a multifunctional polypeptide is produced by a wide variety of cells and regulates a broad array of physiological and pathological functions. TGF-beta appears to play a central role in pulmonary fibrosis and may contribute to tumor-associated immunosuppression. Alveolar macrophages are a rich source of TGF-beta and are intimately involved in lung inflammation. We therefore chose to study TGF-beta regulation in murine alveolar macrophages as well as an immortalized peritoneal macrophage cell line (IC-21). Murine macrophages were incubated with cytokines to evaluate their role in regulating TGF-beta mRNA expression. We conclude that IFN-alpha downregulates TGF-beta mRNA expression in murine macrophages.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 8088926 DOI： 10.1007/bf01534271

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

39 in total

1. Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

Authors: T Tada; S Ohzeki; K Utsumi; H Takiuchi; M Muramatsu; X F Li; J Shimizu; H Fujiwara; T Hamaoka
Journal: J Immunol Date: 1991-02-01 Impact factor: 5.422

2. Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

Authors: J Massagué; B Like
Journal: J Biol Chem Date: 1985-03-10 Impact factor: 5.157

3. Transforming growth factor-beta 1 (TGF-beta 1) and recombinant human tumor necrosis factor-alpha reciprocally regulate the generation of lymphokine-activated killer cell activity. Comparison between natural porcine platelet-derived TGF-beta 1 and TGF-beta 2, and recombinant human TGF-beta 1.

Authors: T Espevik; I S Figari; G E Ranges; M A Palladino
Journal: J Immunol Date: 1988-04-01 Impact factor: 5.422

4. Characterization of the mouse transforming growth factor-beta 1 promoter and activation by the Ha-ras oncogene.

Authors: A G Geiser; S J Kim; A B Roberts; M B Sporn
Journal: Mol Cell Biol Date: 1991-01 Impact factor: 4.272

5. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

Authors: T J Broekelmann; A H Limper; T V Colby; J A McDonald
Journal: Proc Natl Acad Sci U S A Date: 1991-08-01 Impact factor: 11.205

6. Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts.

Authors: J Varga; J Rosenbloom; S A Jimenez
Journal: Biochem J Date: 1987-11-01 Impact factor: 3.857

7. Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells.

Authors: J J Mulé; S L Schwarz; A B Roberts; M B Sporn; S A Rosenberg
Journal: Cancer Immunol Immunother Date: 1988 Impact factor: 6.968

1. Plasmacytoid dendritic cell-derived IFNα modulates Th17 differentiation during early Bordetella pertussis infection in mice.

Authors: V Wu; A A Smith; H You; T A Nguyen; R Ferguson; M Taylor; J E Park; P Llontop; K R Youngman; T Abramson
Journal: Mucosal Immunol Date: 2015-10-14 Impact factor: 7.313

1 in total