Literature DB >> 8088336

An intracisternal A-particle sequence codes for an antigen recognized by syngeneic cytolytic T lymphocytes on a mouse spontaneous leukemia.

V de Bergeyck1, E De Plaen, P Chomez, T Boon, A Van Pel.   

Abstract

Cytolytic T lymphocyte (CTL) clones directed against spontaneous mouse leukemia LEC have been obtained. By transfecting a cosmid library into cells which were then tested for their ability to stimulate the CTL, we identified the gene coding for the antigen recognized by one of these CTL clones. It is the gag gene of an endogenous defective retrovirus that belongs to the intracisternal A particle (IAP) family. A gag-encoded nonapeptide presented by the H-2 Dk molecule caused recognition by the anti-LEC CTL clone. Southern blot and polymerase chain reaction analyses indicated that the expression of the antigen by the LEC tumor cell line resulted from the transposition of an IAP sequence into a new genomic location.

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Year:  1994        PMID： 8088336     DOI： 10.1002/eji.1830240941

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  9 in total

1.  Induction of polyomavirus-specific CD8(+) T lymphocytes by distinct dendritic cell subpopulations.

Authors:  D R Drake; M L Shawver; A Hadley; E Butz; C Maliszewski; A E Lukacher
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

Review 2.  Tumor cells engineered to produce cytokines or cofactors as cellular vaccines: do animal studies really support clinical trials?

Authors:  M P Colombo; M Rodolfo
Journal:  Cancer Immunol Immunother       Date:  1995-11       Impact factor: 6.968

Review 3.  MHC ligands and peptide motifs: first listing.

Authors:  H G Rammensee; T Friede; S Stevanoviíc
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

4.  Identification of the immunodominant H-2K(k)-restricted cytotoxic T-cell epitope in the Borna disease virus nucleoprotein.

Authors:  K Schamel; P Staeheli; J Hausmann
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

5.  Polyomavirus-infected dendritic cells induce antiviral CD8(+) T lymphocytes.

Authors:  D R Drake; J M Moser; A Hadley; J D Altman; C Maliszewski; E Butz; A E Lukacher
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

6.  The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68.

Authors:  P Dubey; R C Hendrickson; S C Meredith; C T Siegel; J Shabanowitz; J C Skipper; V H Engelhard; D F Hunt; H Schreiber
Journal:  J Exp Med       Date:  1997-02-17       Impact factor: 14.307

Review 7.  Retroelements and the human genome: new perspectives on an old relation.

Authors:  Norbert Bannert; Reinhard Kurth
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-13       Impact factor: 11.205

8.  Antiviral CD8+ T cell responses in neonatal mice: susceptibility to polyoma virus-induced tumors is associated with lack of cytotoxic function by viral antigen-specific T cells.

Authors:  J M Moser; J D Altman; A E Lukacher
Journal:  J Exp Med       Date:  2001-03-05       Impact factor: 14.307

9.  Molecular cancer vaccines: Tumor therapy using antigen-specific immunizations.

Authors:  T Schweighoffer
Journal:  Pathol Oncol Res       Date:  1997-09       Impact factor: 2.874
  9 in total

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