Literature DB >> 8088295

Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.

E A Werder1, R Voutilainen, M Zachmann.   

Abstract

In a girl aged 5 years with a virilizing adrenal adenoma the urinary and plasma steroid findings suggested the diagnosis of congenital adrenal hyperplasia due to P450c11 (11 beta-hydroxylase) deficiency. After removal of the tumour clinical signs receded and the hormonal values normalized. RNA analysis of the tumour tissue revealed low amounts of P450c11 mRNA which indicates that P450c11 deficiency of the adenoma caused the steroid abnormalities in this girl.

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Year:  1994        PMID： 8088295     DOI： 10.1007/bf01983403

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  26 in total

1.  ADRENOCORTICAL CARCINOMA WITH FEMINIZATION AND HYPERTENSION ASSOCIATED WITH A DEFECT IN 11-BETA-HYDROXYLATION.

Authors:  C D WEST; L F KUMAGAI; E L SIMONS; O B DOMINGUEZ; D L BERLINER
Journal:  J Clin Endocrinol Metab       Date:  1964-07       Impact factor: 5.958

2.  11 beta-Hydroxydehydroepiandrosterone in a case of virilizing adrenal adenoma: isolation from urine and mitochondrial conversion from dehydroepiandrosterone.

Authors:  J Weidenfeld; J M Shaefer; H Landau; M Schiller; Z Zadik
Journal:  J Clin Endocrinol Metab       Date:  1978-07       Impact factor: 5.958

3.  Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.

Authors:  Y Touitou; P Lecomte; A Auzéby; A Bogdan; Y Besnier
Journal:  Horm Metab Res       Date:  1989-05       Impact factor: 2.936

4.  A virilizing adrenal tumor with borderline elevation of urinary 17-ketosteroids.

Authors:  R David; G August; H M Gandy
Journal:  Pediatrics       Date:  1968-07       Impact factor: 7.124

5.  Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.

Authors:  B C Chung; K J Matteson; R Voutilainen; T K Mohandas; W L Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

6.  Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

Authors:  E Mornet; J Dupont; A Vitek; P C White
Journal:  J Biol Chem       Date:  1989-12-15       Impact factor: 5.157

7.  Testosterone-secreting virilizing adrenal adenoma with human chorionic gonadotrophin receptors and 21-hydroxylase deficiency.

Authors:  P Leinonen; T Ranta; R Siegberg; R Pelkonen; P Heikkilä; A Kahri
Journal:  Clin Endocrinol (Oxf)       Date:  1991-01       Impact factor: 3.478

8.  Normative data for adrenal steroidogenesis in a healthy pediatric population: age- and sex-related changes after adrenocorticotropin stimulation.

Authors:  G Lashansky; P Saenger; K Fishman; T Gautier; D Mayes; G Berg; J Di Martino-Nardi; E Reiter
Journal:  J Clin Endocrinol Metab       Date:  1991-09       Impact factor: 5.958

9.  The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.

Authors:  K M Curnow; M T Tusie-Luna; L Pascoe; R Natarajan; J L Gu; J L Nadler; P C White
Journal:  Mol Endocrinol       Date:  1991-10

10.  Adrenocortical tumor in a patient with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

Authors:  S Pang; D Becker; J Cotelingam; T P Foley; A L Drash
Journal:  Pediatrics       Date:  1981-08       Impact factor: 7.124
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  1 in total

Review 1.  Clinical perspectives in congenital adrenal hyperplasia due to 11β-hydroxylase deficiency.

Authors:  Krupali Bulsari; Henrik Falhammar
Journal:  Endocrine       Date:  2016-12-07       Impact factor: 3.633
  1 in total

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