Literature DB >> 8088070

Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis.

A Oda1, M Miyata, E Kodama, H Satoh, Y Sato, T Nishimaki, H Nomaguchi, R Kasukawa.   

Abstract

Antibodies to 65Kd heat-shock protein (hsp) of mycobacterium leprae were measured by enzyme-linked immunosorbent assay (ELISA) in the three immunoglobulin classes in paired sera and synovial fluids of patients with rheumatoid arthritis (RA). Titers of anti-hsp antibody were expressed by optical density (OD) values for sera or indexes (OD values divided by amounts of immunoglobulin in each class) for synovial fluids and for their paired sera. Indexes of anti-hsp antibody were higher in synovial fluids than those in sera at 15/18 for IgG, 17/18 for IgA and 16/18 for IgM class. These results suggest the participation of anti-hsp antibodies to synovitis in RA.

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Year:  1994        PMID： 8088070     DOI： 10.1007/bf02249023

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  8 in total

1.  Specific antibody response to the mycobacterial 65 kDa stress protein in ankylosing spondylitis and rheumatoid arthritis.

Authors:  I L McLean; J R Archer; M I Cawley; F S Pegley; B L Kidd; P W Thompson
Journal:  Br J Rheumatol       Date:  1990-12

2.  Surface expressed heat-shock proteins by stressed or human immunodeficiency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity.

Authors:  S Di Cesare; F Poccia; A Mastino; V Colizzi
Journal:  Immunology       Date:  1992-06       Impact factor: 7.397

3.  Presence of human 65 kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients.

Authors:  A Karlsson-Parra; K Söderström; M Ferm; J Ivanyi; R Kiessling; L Klareskog
Journal:  Scand J Immunol       Date:  1990-06       Impact factor: 3.487

4.  Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis.

Authors:  E R de Graeff-Meeder; M Voorhorst; W van Eden; H J Schuurman; J Huber; D Barkley; R N Maini; W Kuis; G T Rijkers; B J Zegers
Journal:  Am J Pathol       Date:  1990-11       Impact factor: 4.307

5.  The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

Authors:  S Albani; J E Tuckwell; L Esparza; D A Carson; J Roudier
Journal:  J Clin Invest       Date:  1992-01       Impact factor: 14.808

6.  Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.

Authors:  G Tsoulfa; G A Rook; J D Van-Embden; D B Young; A Mehlert; D A Isenberg; F C Hay; P M Lydyard
Journal:  Ann Rheum Dis       Date:  1989-02       Impact factor: 19.103

7.  A Mycobacterium leprae-specific human T cell epitope cross-reactive with an HLA-DR2 peptide.

Authors:  D C Anderson; W C van Schooten; M E Barry; A A Janson; T M Buchanan; R R de Vries
Journal:  Science       Date:  1988-10-14       Impact factor: 47.728

8.  Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.

Authors:  G Tsoulfa; G A Rook; G M Bahr; M A Sattar; K Behbehani; D B Young; A Mehlert; J D Van-Embden; F C Hay; D A Isenberg
Journal:  Scand J Immunol       Date:  1989-11       Impact factor: 3.487
  8 in total
  6 in total

1.  Anti-heat shock protein 70 kDa and 90 kDa antibodies in serum of patients with rheumatoid arthritis.

Authors:  G Hayem; M De Bandt; E Palazzo; S Roux; B Combe; J F Eliaou; J Sany; M F Kahn; O Meyer
Journal:  Ann Rheum Dis       Date:  1999-05       Impact factor: 19.103

Review 2.  Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?

Authors:  Tangchun Wu; Robert M Tanguay
Journal:  Cell Stress Chaperones       Date:  2006       Impact factor: 3.667

Review 3.  The involvement of heat-shock proteins in the pathogenesis of autoimmune arthritis: a critical appraisal.

Authors:  Min-Nung Huang; Hua Yu; Kamal D Moudgil
Journal:  Semin Arthritis Rheum       Date:  2009-12-06       Impact factor: 5.532

4.  Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase.

Authors:  M Miyata; A Kogure; H Sato; E Kodama; H Watanabe; H Ohira; M Kuroda; T Takagi; Y Sato; R Kasukawa
Journal:  Clin Rheumatol       Date:  1995-11       Impact factor: 2.980

Review 5.  Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune Diseases.

Authors:  Christine Riedhammer; Robert Weissert
Journal:  Front Immunol       Date:  2015-06-17       Impact factor: 7.561

6.  Serum heat-shock protein-65 antibody levels are elevated but not associated with disease activity in patients with rheumatoid arthritis and ankylosing spondylitis.

Authors:  Hasan Ulusoy; Gurkan Akgol; Arif Gulkesen; Arzu Kaya; Gul Ayden Kal; Dilara Kaman; Turkan Tuncer
Journal:  Open Access Rheumatol       Date:  2018-05-25
  6 in total

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