Literature DB >> 8086472

Characterization of the 5'-regulatory region of rat Reg I gene.

H Miyashita1, H Yonekura, M Unno, Y Suzuki, T Watanabe, S Moriizumi, S Takasawa, H Okamoto.   

Abstract

We report here the characterization of the 5'-regulatory region of rat Reg I gene encoding a growth stimulating factor for pancreatic beta-cells. Transient expression assays of the 5'-flanking region/luciferase fusion gene in AR4-2J cells showed that the -304/-237 region contained positive cis-acting elements. Gel shift assays using AR4-2J and rat pancreas nuclear extracts showed the formation of a specific complex with the -256/-237 oligonucleotide.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8086472     DOI： 10.1016/0167-4781(94)90281-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  2 in total

1.  Pancreatic reg gene expression is inhibited during cellular differentiation.

Authors:  M E Zenilman; T H Magnuson; R Perfetti; J Chen; A R Shuldiner
Journal:  Ann Surg       Date:  1997-03       Impact factor: 12.969

2.  Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation.

Authors:  T Akiyama; S Takasawa; K Nata; S Kobayashi; M Abe; N J Shervani; T Ikeda; K Nakagawa; M Unno; S Matsuno; H Okamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.