Literature DB >> 808423

A new improved synthesis of thyrotropin releasing hormone.

G Mattalia, U Bucciarelli.   

Abstract

This synthesis of thyrotropin releasing hormone (TRH) is particularly suitable for large scale production of highly purified TRH, thanks to its high yields of the coupling and deprotection reactions together with the very simple final purification step.

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Year:  1975        PMID： 808423     DOI： 10.1007/BF02358821

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Stimulation of FSH and LH release in vitro by natural and synthetic LH and FSH releasing hormone.

Authors:  A V Schally; T W Redding; H Matsuo; A Arimura
Journal:  Endocrinology       Date:  1972-06       Impact factor: 4.736

2.  [Pyroglutamylpeptides].

Authors:  W König; R Geiger
Journal:  Chem Ber       Date:  1972

3.  Synthesis of pyroglutamylhistidylprolineamide by classical and solid phase methods.

Authors:  G Flouret
Journal:  J Med Chem       Date:  1970-09       Impact factor: 7.446

4.  N-Carbobenzoxy-L-pyroglutamyl-L-hitidyl peptides.

Authors:  P Kurath; A M Thomas
Journal:  Helv Chim Acta       Date:  1973       Impact factor: 2.164

5.  Structure and synthesis of the thyrotropin-releasing hormone.

Authors:  F Enzmann; J Boler; K Folkers; C Y Bowers; A V Schally
Journal:  J Med Chem       Date:  1971-06       Impact factor: 7.446

6.  Synthesis and biological activity of thyrotropin-releasing hormone.

Authors:  C M Baugh; C L Krumdieck; J M Hershman; J A Pittman
Journal:  Endocrinology       Date:  1970-11       Impact factor: 4.736

7.  Syntheses of pyroglutamylhistidylprolinamide and unusual mass fragmentation.

Authors:  J K Chang; H Sievertsson; C Bogentoft; B Currie; K Folkers; G D Daves
Journal:  J Med Chem       Date:  1971-06       Impact factor: 7.446

8.  Synthesis of analogs of the thyrotropin-releasing hormone and structure-activity relationship.

Authors:  J K Chang; H Sievertsson; B Currie; K Folkers; C Bowers
Journal:  J Med Chem       Date:  1971-06       Impact factor: 7.446

9.  Discovery of modification of the synthetic tripeptide-sequence of the thyrotropin releasing hormone having activity.

Authors:  K Folkers; F Enzmann; J Boler; C Y Bowers; A V Schally
Journal:  Biochem Biophys Res Commun       Date:  1969-09-24       Impact factor: 3.575

10.  [Syntheses of thyrotropin-releasing hormones (TRH) (Schaf) and related peptides].

Authors:  D Gillessen; A M Felix; W Lergier; R O Studer
Journal:  Helv Chim Acta       Date:  1970       Impact factor: 2.164
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