| Literature DB >> 8083815 |
C M Franks1, J Hardcastle, P T Hardcastle.
Abstract
The involvement of nitric oxide (NO) in the effects of 5-HT on intestinal secretion and cardiovascular function in anaesthetized rats was investigated using NG-nitro-L-arginine methyl ester (L-NAME), a specific NO-synthase antagonist, and its optical isomer D-NAME. L-NAME significantly reduced the prolonged hypotensive response to 5-HT. It also caused a small rightward shift in the colonic 5-HT dose-response curve. This suggests that NO plays a significant role in the prolonged hypotensive response to 5-HT, and may make a small contribution to the secretory response of the colon, but not that of the jejunum, in the rat in-vivo.Entities:
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Year: 1994 PMID： 8083815 DOI： 10.1111/j.2042-7158.1994.tb03821.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765