| Literature DB >> 8083579 |
C A O'Neill1, B Halliwell, A van der Vliet, P A Davis, L Packer, H Tritschler, W J Strohman, T Rieland, C E Cross, A Z Reznick.
Abstract
Exposure of human plasma to gas phase cigarette smoke (CS) produces a depletion of ascorbic acid, peroxidation of lipids (Frei et al. Biochem J 1991; 277: 133-8), and protein modification (as measured by protein carbonyl accumulation and loss of sulfhydryl groups) (Reznick et al. Biochem J 1992; 286: 607-11). CS contains both saturated and unsaturated aldehydes. The contribution of these aldehydes to the damaging effects of CS on human plasma was investigated. Aldehydes present in CS did not cause a depletion of plasma antioxidants such as ascorbic acid or alpha-tocopherol and did not induce plasma lipid peroxidation. Aldehydes decreased plasma protein sulfhydryl concentrations but increased protein carbonyls. The thiols glutathione and dihydrolipoic acid had a significant effect in reducing aldehyde-induced protein modifications.Entities:
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Year: 1994 PMID： 8083579
Source DB: PubMed Journal: J Lab Clin Med ISSN： 0022-2143