Peripartum liver triglyceride and plasma metabolites in dairy cows.

Nine pregnant, nonlactating cows were used to monitor liver triglycerides before and after parturition. Estimates were made of the contribution of depressed feed intake and parturition to plasma NEFA concentrations and development of fatty liver. Liver biopsies and plasma samples were obtained on d 19, 10, 5, 3, and 1 prior to calving and on d 1, 7, 14, and 21 after calving. Depression of DMI started on d 2 prior to calving and was 40% of DMI on d 3 prior to depression of feed intake. Elevation of plasma NEFA concentrations started prior to DMI depression, on d 5 before parturition. Liver triglyceride infiltration did not occur until the concentration of plasma NEFA was maximized on d 1 after calving. This result implicated the acute rise in NEFA at calving as a contributing factor to triglyceride accumulation in the liver. The increasing plasma glucose and decreasing plasma BHBA prior to calving may have reflected metabolic changes toward gluconeogenesis. Liver glycogen decreased 70% during the final 19 d prior to calving. Hepatic triglyceride infiltration (7.7% DM basis) on d 1 post-partum and duration of DMI depression prepartum were less severe than those observed in previous studies. Frequent liver biopsies did not affect DMI.