Literature DB >> 8083179

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

J P Gaughran1, M H Lai, D R Kirsch, S J Silverman.   

Abstract

Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin synthase isozymes and growth assays with isozyme mutants were used to demonstrate that nikkomycin Z is a selective inhibitor of chitin synthase 3. The resistance of chitin synthase 2 to nikkomycin Z in vitro is likely responsible for the poor activity of this antibiotic against Saccharomyces cerevisiae.

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Year:  1994        PMID： 8083179      PMCID： PMC196793          DOI： 10.1128/jb.176.18.5857-5860.1994

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  26 in total

1.  Effect of calcofluor white on chitin synthases from Saccharomyces cerevisiae.

Authors:  C Roncero; M H Valdivieso; J C Ribas; A Durán
Journal:  J Bacteriol       Date:  1988-04       Impact factor: 3.490

2.  Solubilization and partial purification of yeast chitin synthetase. Confirmation of the zymogenic nature of the enzyme.

Authors:  A Duran; E Cabib
Journal:  J Biol Chem       Date:  1978-06-25       Impact factor: 5.157

3.  Effect of polyoxin D on chitin synthesis and septum formation in Saccharomyces cerevisiae.

Authors:  B Bowers; G Levin; E Cabib
Journal:  J Bacteriol       Date:  1974-08       Impact factor: 3.490

4.  Timing and function of chitin synthesis in yeast.

Authors:  E Cabib; B Bowers
Journal:  J Bacteriol       Date:  1975-12       Impact factor: 3.490

5.  Activation of chitin synthetase in permeabilized cells of a Saccharomyces cerevisiae mutant lacking proteinase B.

Authors:  M P Fernandez; J U Correa; E Cabib
Journal:  J Bacteriol       Date:  1982-12       Impact factor: 3.490

6.  Cloning regulated yeast genes from a pool of lacZ fusions.

Authors:  S W Ruby; J W Szostak; A W Murray
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

7.  Sensitivity to nikkomycin Z in Candida albicans: role of peptide permeases.

Authors:  J C Yadan; M Gonneau; P Sarthou; F Le Goffic
Journal:  J Bacteriol       Date:  1984-12       Impact factor: 3.490

8.  Isolation and characterization of Saccharomyces cerevisiae mutants resistant to Calcofluor white.

Authors:  C Roncero; M H Valdivieso; J C Ribas; A Durán
Journal:  J Bacteriol       Date:  1988-04       Impact factor: 3.490

9.  Two chitin synthases in Saccharomyces cerevisiae.

Authors:  P Orlean
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157

10.  Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae.

Authors:  A Sburlati; E Cabib
Journal:  J Biol Chem       Date:  1986-11-15       Impact factor: 5.157
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  44 in total

1.  Cell wall chitosaccharides are essential components and exposed patterns of the phytopathogenic oomycete Aphanomyces euteiches.

Authors:  Ilham Badreddine; Claude Lafitte; Laurent Heux; Nicholas Skandalis; Zacharoula Spanou; Yves Martinez; Marie-Thérèse Esquerré-Tugayé; Vincent Bulone; Bernard Dumas; Arnaud Bottin
Journal:  Eukaryot Cell       Date:  2008-09-19

Review 2.  Antifungal agents: chemotherapeutic targets and immunologic strategies.

Authors:  N H Georgopapadakou; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

3.  Modulation of Alternaria infectoria cell wall chitin and glucan synthesis by cell wall synthase inhibitors.

Authors:  Chantal Fernandes; Jorge Anjos; Louise A Walker; Branca M A Silva; Luísa Cortes; Marta Mota; Carol A Munro; Neil A R Gow; Teresa Gonçalves
Journal:  Antimicrob Agents Chemother       Date:  2014-03-10       Impact factor: 5.191

4.  Synthesis of anti-1,3 Amino Alcohol Motifs via Pd(II)/SOX Catalysis with the Capacity for Stereodivergence.

Authors:  Rulin Ma; Jonathon Young; Rossella Promontorio; Friederike M Dannheim; Christopher C Pattillo; M Christina White
Journal:  J Am Chem Soc       Date:  2019-06-05       Impact factor: 15.419

Review 5.  Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins.

Authors:  Brigitte M E Hayes; Marilyn A Anderson; Ana Traven; Nicole L van der Weerden; Mark R Bleackley
Journal:  Cell Mol Life Sci       Date:  2014-02-14       Impact factor: 9.261

6.  Co-delivery of cell-wall-forming enzymes in the same vesicle for coordinated fungal cell wall formation.

Authors:  Martin Schuster; Magdalena Martin-Urdiroz; Yujiro Higuchi; Christian Hacker; Sreedhar Kilaru; Sarah J Gurr; Gero Steinberg
Journal:  Nat Microbiol       Date:  2016-08-26       Impact factor: 17.745

7.  Chitin synthases from Saprolegnia are involved in tip growth and represent a potential target for anti-oomycete drugs.

Authors:  Gea Guerriero; Mariano Avino; Qi Zhou; Johanna Fugelstad; Pierre-Henri Clergeot; Vincent Bulone
Journal:  PLoS Pathog       Date:  2010-08-26       Impact factor: 6.823

Review 8.  Chitin synthesis and fungal pathogenesis.

Authors:  Megan D Lenardon; Carol A Munro; Neil A R Gow
Journal:  Curr Opin Microbiol       Date:  2010-06-08       Impact factor: 7.934

9.  The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function.

Authors:  Peter R Kraus; Deborah S Fox; Gary M Cox; Joseph Heitman
Journal:  Mol Microbiol       Date:  2003-06       Impact factor: 3.501

10.  Cell wall stress induces alternative fungal cytokinesis and septation strategies.

Authors:  Louise A Walker; Megan D Lenardon; Kanya Preechasuth; Carol A Munro; Neil A R Gow
Journal:  J Cell Sci       Date:  2013-04-19       Impact factor: 5.285
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