Some properties of interferons induced by stimulants of T and B lymphocytes.

Murine interferons induced by viruses and by non viral substances such as lectins, tilorone, lipopolysaccharide and Brucella have been analysed by affinity chromatography on a column of Sepharose coupled to anti-bodies directed against viral interferon. B cell stimulants induced interferons which are antigenically related to viral interferon and T cell dependent mitogens induced an interferon species which appears to be antigenically and physicochemically different. Despite their antigenic differences, both kinds of interferon seem to follow similar pathways for the induction of the antiviral state (sensitivity to antimetabolites, and in vitro phosphorylation of a 67 000 MW protein).