Literature DB >> 8082762

Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels.

J A Paynter1, A Grimes, P Lockhart, J F Mercer.   

Abstract

The expression of the homologue of the Menkes disease gene (Mnk) in mice was studied using RNA blots. The highest level of expression of the 8.0 kb mRNA was found in placenta, substantial expression was noted in lung, heart, brain, testis and kidney and gut mucosa, but very low levels were found in spleen and adult liver. In fetal liver, the amount of Mnk mRNA is similar to that found in kidney, however, it declines soon after birth. Results with copper-loaded normal mice and mutant mice with genetic defects in copper transport suggested that Mnk mRNA levels are not regulated by tissue copper concentrations.

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Year:  1994        PMID： 8082762     DOI： 10.1016/0014-5793(94)00868-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

Authors:  Byung-Eun Kim; Michelle L Turski; Yasuhiro Nose; Michelle Casad; Howard A Rockman; Dennis J Thiele
Journal:  Cell Metab       Date:  2010-05-05       Impact factor: 27.287

2.  Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein (ATP7B).

Authors:  Michael A Cater; Sharon La Fontaine; Julian F B Mercer
Journal:  Biochem J       Date:  2007-01-01       Impact factor: 3.857

3.  Expression of Menkes disease gene in mammary carcinoma cells.

Authors:  M L Ackland; E J Cornish; J A Paynter; A Grimes; A Michalczyk; J F Mercer
Journal:  Biochem J       Date:  1997-11-15       Impact factor: 3.857

4.  Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.

Authors:  M J Petris; J F Mercer; J G Culvenor; P Lockhart; P A Gleeson; J Camakaris
Journal:  EMBO J       Date:  1996-11-15       Impact factor: 11.598

Review 5.  Menkes copper-translocating P-type ATPase (ATP7A): biochemical and cell biology properties, and role in Menkes disease.

Authors:  Ilia Voskoboinik; James Camakaris
Journal:  J Bioenerg Biomembr       Date:  2002-10       Impact factor: 2.945

6.  Participation of ATP7A in macrophage mediated oxidation of LDL.

Authors:  Zhenyu Qin; Eddy S Konaniah; Bonnie Neltner; Raphael A Nemenoff; David Y Hui; Neal L Weintraub
Journal:  J Lipid Res       Date:  2009-11-23       Impact factor: 5.922

7.  Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.

Authors:  Michael A Cater; John Forbes; Sharon La Fontaine; Diane Cox; Julian F B Mercer
Journal:  Biochem J       Date:  2004-06-15       Impact factor: 3.857

8.  Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes.

Authors:  Patricia Muller; Harm van Bakel; Bart van de Sluis; Frank Holstege; Cisca Wijmenga; Leo W J Klomp
Journal:  J Biol Inorg Chem       Date:  2007-01-09       Impact factor: 3.862

9.  Abnormal Development of Neural Stem Cell Niche in the Dentate Gyrus of Menkes Disease.

Authors:  Sung-Kuk Cho; Suhyun Gwon; Hyun Ah Kim; Jiwon Kim; Sung Yoo Cho; Dong-Eog Kim; Jong-Hee Chae; Dae Hwi Park; Yu Kyeong Hwang
Journal:  Int J Stem Cells       Date:  2022-02-28       Impact factor: 3.011

Review 10.  Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper.

Authors:  Sian L Stafford; Nilesh J Bokil; Maud E S Achard; Ronan Kapetanovic; Mark A Schembri; Alastair G McEwan; Matthew J Sweet
Journal:  Biosci Rep       Date:  2013-07-16       Impact factor: 3.840
  10 in total

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