| Literature DB >> 8081649 |
M M Pater1, R Mittal, A Pater.
Abstract
Human papillomaviruses (HPVs) are etiologically involved in cervical neoplasia, and epidemiological evidence suggests that steroid hormones can increase the risk of this cancer in HPV-infected women. Steroids can interact with hormone-response elements in the viral long control region, enhancing HPV transcription and resulting in transformation of cervical cells. Subsequent malignant progression may involve virus-induced chromosomal instability, facilitating viral DNA integration and deregulation of gene expression.Entities:
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Year: 1994 PMID： 8081649 DOI： 10.1016/0966-842x(94)90627-0
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079