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Literature DB >> 8080736

Is an increase in CA 125 in breast cancer patients an indicator of pleural metastases?

W Jäger¹, A Kissing, S Cilaci, R Melsheimer, N Lang.

Abstract

The retrospective analysis of 250 breast cancer patients with disseminated disease provided evidence that the increase in CA 125 serum levels in these patients was caused by lung metastases or pleural effusions. Seven patients with lung metastases and pleural involvement had elevated CA 125 levels, while in four patients with lung metastases but without pleural effusions CA 125 levels remained normal. In patients with only bone or liver metastases CA 125 levels were usually not elevated. If these results are confirmed, CA 125 would be the first tumour marker in breast cancer whose levels could be associated with one single site of metastases.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 8080736 PMCID： PMC2033344 DOI： 10.1038/bjc.1994.333

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

14 in total

1. Distribution of CA 125 in embryonic tissues and adult derivatives of the fetal periderm.

Authors: H Hardardottir; T H Parmley; J G Quirk; M M Sanders; F C Miller; T J O'Brien
Journal: Am J Obstet Gynecol Date: 1990-12 Impact factor: 8.661

2. Serum CA-125 as a guideline for the timing of a second-look operation and second-line treatment in ovarian cancer.

Authors: W Jäger; R Adam; L Wildt; N Lang
Journal: Arch Gynecol Obstet Date: 1988 Impact factor: 2.344

3. Diagnostic significance of cancer antigen 125, pancreatic oncofetal antigen, and carcinoembryonic antigen in malignant and tuberculous pleural effusions.

Authors: Y Niwa; K Shimokata
Journal: Jpn J Clin Oncol Date: 1986-03 Impact factor: 3.019

Is an increase in CA 125 in breast cancer patients an indicator of pleural metastases?

1. Distribution of CA 125 in embryonic tissues and adult derivatives of the fetal periderm.

2. Serum CA-125 as a guideline for the timing of a second-look operation and second-line treatment in ovarian cancer.

3. Diagnostic significance of cancer antigen 125, pancreatic oncofetal antigen, and carcinoembryonic antigen in malignant and tuberculous pleural effusions.

4. Evaluation of serum CA 125 as a tumor marker in non-small cell lung cancer.

5. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125.

6. Circulating tumor marker levels in advanced breast carcinoma correlate with the extent of metastatic disease.

7. Marker profile of mesothelial cells versus ovarian carcinoma cells.

8. Serum CA125 level is a good prognostic indicator in lung cancer.

9. Elevated CA125 levels in patients with metastatic breast carcinoma.

10. CA-125 is not a useful marker in metastatic breast cancer.

1. Mesorectum localization as a special kind of rectal metastasis from breast cancer.

Review 2. Oncofetal reprogramming in tumour development and progression.