HPLC determination of sodium cromoglycate in pharmaceutical dosage forms.

A reversed-phase high-performance liquid chromatography (HPLC) method is described for the determination of sodium chromoglycate (SCG) in bulk drug and pharmaceutical dosage forms (capsules, solutions, gels). Aliquots were chromatographed on C18 columns using methanol: phosphate buffer (50:50 v/v) at pH 2.3 as the mobile phase. Detection was performed at 326 nm with a linear range of 0.05-0.5 microgram/ml (r = 0.9999). Recovery values ranged from 99.21 to 106.31% (N = 9). The proposed method is rapid and simple, free from interference by excipient and degradation products, and can be recommended for routine control analysis of sodium chromoglycate commercial products and magistral formulations.