Literature DB >> 8079831

Influence of cyclosporin A on cytokine levels in synovial fluid and serum of rats with antigen-induced arthritis.

R Bräuer1, H Kette, S Henzgen, K Thoss.   

Abstract

The effects of the T-cell-directed immunosuppressant cyclosporin A (CsA) on the development of antigen-induced arthritis (AIA) in rats as well as on cytokine levels in synovial fluid and serum were determined. The treatment with CsA effectively inhibited the chronic phase of arthritis as demonstrated by decreased joint swelling and reduced histological arthritic score. In animals with AIA the level of IL-6 in the synovial fluid and serum is increased, showing good correlation with the severity of the disease. The CsA treatment reduced IL-6 levels to normal. IL-1, IL-2 and TNF-alpha do not seem to be directly involved in the pathogenic mechanisms of chronic arthritis.

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Year:  1994        PMID： 8079831     DOI： 10.1007/bf01986404

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

Review 1.  Use of monoclonal antibodies in vivo as a therapeutic strategy for alloimmune or autoimmune reactivity: the Besançon experience.

Authors:  P Herve; E Racadot; D Wendling; L Rumbach; P Tiberghien; J Y Cahn; M Flesch; J Wijdenes
Journal:  Immunol Rev       Date:  1992-10       Impact factor: 12.988

2.  A method for the quantitative analysis and standardization of interleukin-1 bioactivity.

Authors:  T Krakauer; H Krakauer
Journal:  J Leukoc Biol       Date:  1991-08       Impact factor: 4.962

3.  Studies on antigen-induced arthritis in mice. II. Immunologic correlates of arthritis susceptibility in mice.

Authors:  D Brackertz; G F Mitchell; M A Vadas; I R Mackay; J F Miller
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

4.  Production of interleukin 1 in the joint during the development of antigen-induced arthritis in the rabbit.

Authors:  B Henderson; F M Rowe; C R Bird; A J Gearing
Journal:  Clin Exp Immunol       Date:  1988-12       Impact factor: 4.330

5.  Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A.

Authors:  W Feist; A J Ulmer; M H Wang; J Musehold; C Schlüter; J Gerdes; H Herzbeck; H Brade; S Kusumoto; T Diamantstein
Journal:  FEMS Microbiol Immunol       Date:  1992-01

6.  Interleukin 2 (IL 2) inhibitor in rheumatoid synovial fluid: correlation with prognosis and soluble IL 2 receptor levels.

Authors:  P Miossec; M Elhamiani; B Chichehian; A D D'Angeac; J Sany; M Hirn
Journal:  J Clin Immunol       Date:  1990-03       Impact factor: 8.317

7.  Significance of cell-mediated and humoral immunity in the acute and chronic phase of antigen-induced arthritis in rabbits.

Authors:  R Bräuer; K Thoss; S Henzgen; G Waldmann
Journal:  Exp Pathol       Date:  1988
  7 in total
  11 in total

1.  Immunomodulation of rat antigen-induced arthritis by leflunomide alone and in combination with cyclosporin A.

Authors:  K Thoss; S Henzgen; P K Petrow; D Katenkamp; R Brauer
Journal:  Inflamm Res       Date:  1996-02       Impact factor: 4.575

2.  Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production.

Authors:  D R Haynes; S J Gadd; M W Whitehouse; G Mayrhofer; B Vernon-Roberts
Journal:  Inflamm Res       Date:  1996-04       Impact factor: 4.575

3.  Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporin A.

Authors:  L M Ayer; A C Issekutz; C C Waterhouse; A W Stadnyk
Journal:  Inflammation       Date:  2000-10       Impact factor: 4.092

4.  Combination therapy with dexamethasone and osteoprotegerin protects against arthritis-induced bone alterations in antigen-induced arthritis of the rat.

Authors:  P Oelzner; S Fleissner-Richter; R Bräuer; G Hein; G Wolf; T Neumann
Journal:  Inflamm Res       Date:  2010-03-20       Impact factor: 4.575

5.  Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: influence on T helper cell activation.

Authors:  D Pohlers; K Nissler; O Frey; J Simon; P K Petrow; R W Kinne; R Bräuer
Journal:  Clin Exp Immunol       Date:  2004-03       Impact factor: 4.330

6.  Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation.

Authors:  K Nissler; D Pohlers; M Hückel; J Simon; R Bräuer; R W Kinne
Journal:  Ann Rheum Dis       Date:  2004-11       Impact factor: 19.103

7.  Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis.

Authors:  Taku Nagai; Akira Kyo; Kazuhisa Hasui; Sonshin Takao; Takami Matsuyama
Journal:  Arthritis Res Ther       Date:  2012-05-02       Impact factor: 5.156

8.  Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis.

Authors:  Dirk Pohlers; Angela Siegling; Eberhard Buchner; Carsten B Schmidt-Weber; Ernesta Palombo-Kinne; Frank Emmrich; Rolf Bräuer; Raimund W Kinne
Journal:  Arthritis Res Ther       Date:  2005-02-17       Impact factor: 5.156

9.  Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis.

Authors:  Andreas Roth; Jürgen Mollenhauer; Andreas Wagner; Reneè Fuhrmann; Albrecht Straub; Rudolf A Venbrocks; Peter Petrow; Rolf Bräuer; Harald Schubert; Jörg Ozegowski; Gundela Peschel; Peter J Müller; Raimund W Kinne
Journal:  Arthritis Res Ther       Date:  2005-03-31       Impact factor: 5.156

10.  Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis.

Authors:  Matthias Ebbinghaus; Gisela Segond von Banchet; Julia Massier; Mieczyslaw Gajda; Rolf Bräuer; Michaela Kress; Hans-Georg Schaible
Journal:  Arthritis Res Ther       Date:  2015-11-21       Impact factor: 5.156
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